Testicular cancer is cancer that starts in the testicles, the male reproductive glands located in the scrotum.
Cancer - testes; Germ cell tumor; Seminoma testicular cancer; Nonseminoma testicular cancer
The exact cause of testicular cancer is unknown. Factors that may increase a man's risk of developing testicular cancer increases if he has:
- Abnormal testicle development
- Exposure to certain chemicals
- Family history of testicular cancer
- HIV infection
- History of testicular cancer
- History of an undescended testicle (one or both testicles fail to move into the scrotum before birth)
- Klinefelter syndrome
Testicular cancer is the most common cancer in men between the ages of 15 and 35. It can occur in older men, and in rare cases, in younger boys.
White men are more likely than African American and Asian American men to develop this type of cancer.
There is no link between vasectomy and testicular cancer.
There are two main types of testicular cancer, seminomas and nonseminomas. These cancers grow from germ cells, the cells that make sperm.
Seminoma: This is a slow-growing form of testicular cancer usually found in men in their 30s and 40s. The cancer is usually just in the testes, but it can spread to the lymph nodes. Seminomas are very sensitive to radiation therapy.
Nonseminoma: This more common type of testicular cancer tends to grow more quickly than seminomas.
Nonseminoma tumors are often made up of more than one type of cell, and are identified according to these different cell types:
- Choriocarcinoma (rare)
- Embryonal carcinoma
- Yolk sac tumor
A stromal tumor is a rare type of testicular tumor. They are usually not cancerous. The two main types of stromal tumors are Leydig cell tumors and Sertoli cell tumors. Stromal tumors usually occur during childhood.
There may be no symptoms. If there are symptoms, they may include:
- Discomfort or pain in the testicle, or a feeling of heaviness in the scrotum
- Pain in the back or lower abdomen
- Enlarged testicle or a change in the way it feels
- Excess amount of breast tissue (gynecomastia), however this can occur normally in adolescent boys who do not have testicular cancer
- Lump or swelling in either testicle
Symptoms in other parts of the body, such as the lungs, abdomen, pelvis, back, or brain, may also occur if the cancer has spread outside the testicles.
Exams and Tests
A physical examination typically reveals a firm lump (mass) in one of the testicles. When the health care provider holds a flashlight up to the scrotum, the light does not pass through the lump.
Other tests include:
- Abdominal and pelvic CT scan
- Blood tests for tumor markers: alpha fetoprotein (AFP), human chorionic gonadotrophin (beta HCG), and lactic dehydrogenase (LDH)
- Chest x-ray
- Ultrasound of the scrotum
Treatment depends on the:
- Type of testicular tumor
- Stage of the tumor
Once cancer is found, the first step is to determine the type of cancer cell by examining it under a microscope. The cells can be seminoma, nonseminoma, or both.
The next step is to determine how far the cancer has spread to other parts of the body. This is called "staging."
- Stage I cancer has not spread beyond the testicle.
- Stage II cancer has spread to lymph nodes in the abdomen.
- Stage III cancer has spread beyond the lymph nodes (it could be as far as the liver, lungs, or brain).
Three types of treatment can be used.
- Surgical treatment removes the testicle (orchiectomy) and may also remove nearby lymph nodes (lymphadenectomy). This is usually performed in the case of both seminoma and nonseminomas.
- Radiation therapy using high-dose x-rays or other high-energy rays may be used after surgery to prevent the tumor from returning. Radiation therapy is usually only used for treating seminomas.
- Chemotherapy uses drugs to kill cancer cells. This treatment has greatly improved survival for patients with both seminomas and nonseminomas.
Joining a support group where members share common experiences and problems can often help the stress of illness.
Testicular cancer is one of the most treatable and curable cancers.
The survival rate for men with early-stage seminoma (the least aggressive type of testicular cancer) is greater than 95%. The disease-free survival rate for Stage II and III cancers is slightly lower, depending on the size of the tumor and when treatment is begun.
Testicular cancer may spread to other parts of the body. The most common sites include the:
- Retroperitoneal area (the area near the kidneys behind the other organs in the belly area)
Complications of surgery can include:
- Bleeding and infection after surgery
- Infertility (if both testicles are removed)
If you think you may want to have children in the future, ask your doctor about methods to save your sperm for use at a later date.
When to Contact a Medical Professional
Call your health care provider if you have symptoms of testicular cancer.
Performing a testicular self-examination (TSE) each month may help detect testicular cancer at an early stage, before it spreads. Finding testicular cancer early is important to successful treatment and survival.
Friedlander TW, Ryan CJ, Small EJ, Torti F. Testicular cancer. In: Niederhuber JE, Armitage JO, Doroshow JH, et al., eds. Abeloff's Clinical Oncology. 5th ed. Philadelphia, PA: Elsevier Churchill Livingstone; 2013:chap 86.
National Cancer Institute: PDQ Testicular Cancer Treatment. Bethesda, MD: National Cancer Institute. Date last modified 04/02/2014. Available at http://cancer.gov/cancertopics/pdq/treatment/testicular/HealthProfessional. Accessed May 29, 2014.
National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines): Testicular cancer. Version 1.2014. Available at http://www.nccn.org/professionals/physician_gls/pdf/testicular.pdf. Accessed May 29, 2014.
Reviewed By: Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.