Bence-Jones protein - quantitative
This test measures the level of abnormal proteins called Bence-Jones proteins in the urine.
Immunoglobulin light chains - urine; Urine Bence-Jones protein
How the Test is Performed
A clean-catch urine sample is needed. The clean-catch method is used to prevent germs from the penis or vagina from getting into a urine sample. To collect your urine, the health care provider may give you a special clean-catch kit that contains a cleansing solution and sterile wipes. Follow instructions exactly so that the results are accurate.
How the Test will Feel
The test involves only normal urination, and there is no discomfort.
Why the Test is Performed
Bence-Jones proteins are a part of regular antibodies called light chains. These proteins are not normally in urine. Sometimes, when your body makes too many antibodies, the level of light chains also rises. Bence-Jones proteins are small enough to be filtered out by the kidneys. Then they spill over into the urine.
Your doctor may order this test:
- To diagnose health conditions that lead to protein in the urine
- If you have a lot of protein in your urine
- If you have signs of multiple myeloma
Urine immunofixation is a better test for detecting Bence-Jones proteins.
A normal result means no Bence-Jones proteins are found in your urine.
What Abnormal Results Mean
Bence-Jones proteins are rarely found in urine. If they are, it is usually associated with multiple myeloma.
An abnormal result may also be due to:
- Chronic lymphocytic leukemia
- Lymph system cancer (lymphoma)
- Monoclonal gammopathy of unknown significance (MGUS)
- Waldenstrom macroglobulinemia
McPherson RA, Ben-Ezra J. Basic examination of urine. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 22nd ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 28.
Reviewed By: Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital, Boston, MA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.