Partial thromboplastin time (PTT)
Partial thromboplastin time (PTT) is a blood test that looks at how long it takes for blood to clot. It can help tell if you have a bleeding problem or if your blood does not clot properly.
A related blood test is prothrombin time (PT).
APTT; PTT; Activated partial thromboplastin time
How the Test is Performed
A blood sample is needed. If you are taking any blood-thinning medicines, you will be watched for signs of bleeding.
How to Prepare for the Test
Your health care provider may tell you to temporarily stop taking medicines that may affect the test results. Be sure to tell your provider about all the medicines you take. These include:
- Blood thinners, such as aspirin and heparin, that make it hard for the blood to clot
- Vitamin C
Never stop taking any medicine without first talking to your doctor.
How the Test will Feel
When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or slight bruising. This soon goes away.
Why the Test is Performed
You may need this test if you have problems with bleeding or your blood does not clot properly. When you bleed, a series of actions involving many different proteins (clotting factors) take place in the body that help the blood clot. This is called the coagulation cascade. The PTT test looks at some of the proteins or factors involved in this process and measures their ability to help blood clot.
The test may also be used to monitor patients who are taking heparin, a blood thinner.
A PTT test is usually done with other tests, such as the prothrombin test.
In general, clotting should occur within 25 to 35 seconds. If the person is taking blood thinners, clotting takes up to two-and-a-half times longer.
Normal value ranges may vary slightly among different labs. Some lab use different measurements or may test different specimens. Talk to your doctor about your test results.
What Abnormal Results Mean
An abnormal (too long) PTT result may also be due to:
- Bleeding disorders, a group of conditions in which there is a problem with the body's blood clotting process
- Disorder in which the proteins that control blood clotting become over active (disseminated intravascular coagulation)
- Liver disease
- Difficulty absorbing nutrients from food (malabsorption)
- Low level of vitamin K
This test is often done on people who may have bleeding problems. Their risk of bleeding is slightly higher than it is for people without bleeding problems.
Other slight risks may include:
- Fainting or feeling lightheaded
- Hematoma (blood accumulating under the skin)
- Infection (a slight risk any time the skin is broken)
- Multiple punctures to locate veins
Fink LM, Marlar RA, Miller JL. Antithrombotic therapy. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 22nd ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 42.
Schmaier AH, Miller JL. Coagulation and fibrinolysis. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 22nd ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 39.
Reviewed By: Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital, Boston, MA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.