A granuloma is a small clump of cells that forms when the immune system tries to fight off a harmful substance but cannot remove it from the body.
A necrotizing granuloma is an area of inflammation in which tissue has died. Necrotizing means dying or decaying. See: Necrotic.
Tuberculosis and Wegener's granulomatosis are conditions that cause necrotizing granulomas.
Reviewed By: Linda J. Vorvick, MD, Medical Director and Director of Didactic Curriculum, MEDEX Northwest Division of Physician Assistant Studies, Department of Family Medicine, UW Medicine, School of Medicine, University of Washington. Also reviewed by David Zieve, MD, MHA, Bethanne Black, and the A.D.A.M. Editorial team.