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Propranolol (By mouth)

Propranolol (proe-PRAN-oh-lol)

Treats high blood pressure, angina, uneven heartbeat, and tremors, and prevents migraine headaches. Also lowers health risks after a heart attack. This medicine is a beta-blocker.

Brand Name(s):

Inderal LA, Inderal XL, InnoPran XL, Innopran XL

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use if you had an allergic reaction to propranolol, or if you have asthma or certain heart problems. Talk with your doctor about what these heart problems are.

How to Use This Medicine:

Long Acting Capsule, Liquid, Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Swallow the extended-release capsule whole. Do not crush, break, or chew it.
  • Extended-release capsule: Take at bedtime. This medicine may be taken with or without food, but always take it the same way each time.
  • Oral liquid: Measure your dose with the dropper that comes with the package. You may mix the liquid with water or juice to make it easier to swallow.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some foods and medicines can affect how propranolol works. Tell your doctor if you are using any of the following medicines:
    • Bupropion, chlorpromazine, cimetidine, ciprofloxacin, digoxin, dobutamine, fluconazole, fluoxetine, montelukast, phenytoin, rifampin, theophylline, thioridazine, or ticlopidine
    • Other blood pressure medicine (such as clonidine, diltiazem, nicardipine, nifedipine, nisoldipine, prazosin, verapamil), medicine for heart rhythm problems (such as propafenone, quinidine), medicine to lower cholesterol (such as cholestyramine, colestipol, lovastatin, pravastatin), medicine to treat migraine headaches (such as rizatriptan, zolmitriptan), an MAO inhibitor, medicine to treat depression, NSAID pain or arthritis medicine, or a blood thinner (such as warfarin)

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, angina (chest pain), congestive heart failure, diabetes, glaucoma, breathing problems, an overactive thyroid, or a recent heart attack. Tell your doctor if you have Wolff-Parkinson-White syndrome or a history of severe allergic reactions.
  • This medicine may cause the following problems:
    • Worsening of chest pain, heart attack (if treatment is stopped suddenly)
    • Heart failure
    • Low blood sugar levels
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • This medicine may make you dizzy, drowsy, or lightheaded. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Chest pain (may be related to your heart disease and not a side effect)
  • Lightheadedness, dizziness, or fainting
  • Rapid weight gain, swelling in your hands, ankles, or feet, trouble breathing, tiredness
  • Slow, fast, or uneven heartbeat

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 7/4/2014

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