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Triamterene/hydrochlorothiazide (By mouth)

Hydrochlorothiazide (hye-droe-klor-oh-THYE-a-zide), Triamterene (trye-AM-ter-een)

Treats fluid retention (edema) and high blood pressure. This medicine is a combination of two types of diuretic (water pill).

Brand Name(s):

Dyazide, Maxzide, Maxzide-25

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to triamterene, hydrochlorothiazide, or sulfa drugs (such as sulfamethoxazole/trimethoprim, Bactrim®, Septra®). You should not use this medicine if you are not able to urinate (anuria), have severe kidney disease, or high blood potassium (hyperkalemia). You should not use this medicine if you are also using potassium supplements or salt substitutes or certain diuretics such as amiloride (Midamor®, Moduretic®), spironolactone (Aldactazide®, Aldactone®), or other products containing triamterene.

How to Use This Medicine:

Capsule, Tablet

  • Take your medicine as directed.
  • This medicine should not be the first medicine you use to treat your condition. It is meant to be used only after you have tried other medicines that have not worked or have caused unwanted side effects.
  • Carefully follow your doctor's instructions about any special diet. Be sure to drink plenty of fluids if you exercise, sweat more than usual, or have diarrhea or vomiting.
  • Use only the brand of medicine your doctor prescribed. Other brands may not work the same way.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using cyclosporine (Gengraf®, Neoral®, Sandimmune®), cholestyramine (Questran®), colestipol (Colestid®), digoxin (Lanoxin®), dofetilide (Tikosyn?), lithium (Eskalith®, Lithobid®), methotrexate (Rheumatrex®), diabetes medicine that you take by mouth (such as chlorpropamide, Diabenese®), pain or arthritis medicine (such as aspirin, ibuprofen, indomethacin, Advil®, Aleve®, Indocin®, Motrin®, Orudis®, or Relafen®), tacrolimus (Prograf®), steroid medicine (such as corticotropin, cortisone, prednisone, or Medrol®), or other blood pressure (such as enalapril, lisinopril, Accupril®, Altace®, Lotensin®, Lotrel®, Monopril®, Prinivil®, Zestoretic®, or Zestril®), or low-salt milk.
  • Tell your doctor if you are using methenamine Hiprex®, Mandelamine®, Urex®), norepinephrine, sodium polystyrene sulfonate (Kayexalate®), tubocurarine, a laxative (such as bisacodyl, Dulcolax®), or a blood thinner (such as warfarin, Coumadin®).
  • Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have liver disease (including cirrhosis), diabetes, glaucoma, gout, lupus, pancreatitis, weakened immune system, electrolyte imbalance (such as low chloride, potassium, or sodium), or a history of kidney stones.
  • This medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life.
  • This medicine may increase the amount of potassium in your blood (hyperkalemia). Stop using this medicine and check with your doctor right away if you are having abdominal or stomach pain; confusion; difficulty with breathing; irregular heartbeats; nausea or vomiting; nervousness; numbness or tingling in the hands, feet, or lips; shortness of breath; or weakness or heaviness of the legs.
  • Stop using this medicine and check with your doctor immediately if blurred vision, difficulty in reading, eye pain, or any other change in vision occurs during or after treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).
  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert. Dizziness may be worse if you lose too much water from your body. You can lose water by sweating, having diarrhea, or vomiting. Tell your doctor if this medicine makes you feel lightheaded or dizzy after you have been vomiting or had diarrhea.
  • Check with your doctor right away if you experience dizziness, fainting, confusion, muscle pain, weakness, and/or a fast heartbeat. Use extra care if you exercise or if the weather is hot. Heavy sweating can cause dehydration (loss of too much water) or electrolyte imbalances (loss of sodium, potassium, or magnesium in the body).
  • This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.
  • Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • If you stop using this medicine, your blood pressure may go up. High blood pressure usually has no symptoms. Even if you feel well, do not stop using the medicine without asking your doctor.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments. Blood and urine tests may be needed to check for unwanted effects.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash.
  • Blood in the urine or stools.
  • Blurred vision or changes in vision.
  • Burning, redness, or swelling of the tongue.
  • Change in how much or how often you urinate.
  • Confusion, weakness, uneven heartbeat, shortness of breath, or numbness or tingling in your hands, feet, or lips.
  • Dry mouth, increased thirst, muscle cramps, nausea, or vomiting.
  • Fever, chills, cough, hoarseness, and body aches.
  • Lightheadedness or fainting.
  • Problems urinating, pain in side or lower back.
  • Severe diarrhea or stomach pain.
  • Unusual bleeding or bruising.
  • Unusual tiredness or weakness.

If you notice these less serious side effects, talk with your doctor:

  • Loss of appetite.
  • Mild nausea, vomiting, diarrhea, or stomach upset.
  • Mild skin rash or itching.
  • Problems having sex.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 7/4/2014


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