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Oxycodone/acetaminophen (By mouth)

Acetaminophen (a-seet-a-MIN-oh-fen), Oxycodone Hydrochloride (ox-i-KOE-done hye-droe-KLOR-ide)

Treats moderate to moderately severe pain. This medicine contains a narcotic pain reliever.

Brand Name(s):

Endocet, Magnacet, Percocet, Primalev, Primlev, Roxicet, Xolox

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to acetaminophen or oxycodone, or if you have serious breathing problems (such as severe asthma, hypercarbia, respiratory depression) or paralytic ileus.

How to Use This Medicine:

Capsule, Liquid, Tablet

  • Take your medicine as directed.
  • You may take this medicine with food or milk if it upsets your stomach.
  • Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.
  • Drink plenty of liquids to help avoid constipation.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Do not throw any unused medicine in the trash. Flush it down the toilet or take it to a community take-back program when available. You will also need to throw away old medicine after the expiration date has passed.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines and foods can affect how this medicine works. Tell your doctor if you are taking any of the following:
    • Butorphanol, lamotrigine, nalbuphine, naltrexone, pentazocine, propranolol, zidovudine
    • Birth control pills, a diuretic (water pill), muscle relaxants, a phenothiazine medicine (such as prochlorperazine)
  • Do not drink alcohol while you are using this medicine. Acetaminophen can damage your liver, and alcohol can increase this risk. Do not take acetaminophen without asking your doctor if you have 3 or more drinks of alcohol every day.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney, liver, or heart disease, or low blood pressure. Tell your doctor if you have breathing problems or lung disease, especially if you have asthma, COPD, cor pulmonale, kyphoscoliosis (curved spine that causes breathing trouble). Also tell your doctor if you have urination problems, an underactive thyroid, Addison disease, pancreas or prostate problems, or a stomach disorder. Tell your doctor if you have a history of head injury or brain damage, seizures, or alcohol or drug abuse. Tell your doctor if you are allergic to codeine.
  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
  • This medicine contains acetaminophen. Read the labels of all other medicines you are using to see if they also contain acetaminophen, or ask your doctor or pharmacist. Do not use more than 4 grams (4,000 milligrams) total of acetaminophen in one day.
  • If you take this medicine for more than a few weeks, do not stop taking it suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • Get emergency help immediately if you think you may have taken too much of this medicine. Signs of an overdose include shallow breathing, fainting, confusion, nausea, vomiting, pinpoint pupils of the eyes, or pale or blue lips, fingernails, or skin.
  • This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Extreme weakness, shallow breathing, uneven heartbeat, seizures, sweating, or cold or clammy skin
  • Lightheadedness, dizziness, or fainting
  • Trouble breathing or shortness of breath

If you notice these less serious side effects, talk with your doctor:

  • Constipation
  • Mild lightheadedness, sleepiness, or drowsiness
  • Mild nausea or vomiting

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 4/4/2014
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