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Indomethacin (By mouth)

Indomethacin (in-doe-METH-a-sin)

Treats pain. This is an NSAID.

Brand Name(s):

Indocin, Indocin SR

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction (including asthma) to indomethacin, aspirin, or other NSAIDs. Do not use this medicine right before or right after having a coronary artery bypass graft (CABG), a type of heart surgery.

How to Use This Medicine:

Capsule, Long Acting Capsule, Liquid

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • It is best to take this medicine with food, milk, or antacids so it does not upset your stomach.
  • Swallow the extended-release capsule whole. Do not crush, break, or chew it.
  • Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup. Shake well before using.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Do not freeze the oral liquid.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use any other NSAID medicine unless your doctor says it is okay. Some other NSAIDs are aspirin, diclofenac, diflunisal, ibuprofen, or naproxen.
  • Some medicines can affect how indomethacin works. Tell your doctor if you are using a blood thinner (such as warfarin), a steroid medicine, a diuretic (water pill), blood pressure medicine, cyclosporine, digoxin, lithium, methotrexate, or probenecid.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding. Do not use this medicine during the later part of a pregnancy unless your doctor tells you to.
  • Tell your doctor if you have a history of ulcers or other stomach problems, or if you have kidney disease, liver disease, asthma, bleeding problems, high blood pressure, heart failure, or heart or circulation problems. Tell your doctor if you have a history of depression, mental illness, epilepsy, or Parkinson disease.
  • This medicine may cause the following problems:
    • Higher risk of heart attack or stroke
    • Bleeding in your stomach or intestines
    • Liver problems
    • Serious skin reactions
    • Changes in vision
  • This medicine may make you drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash
  • Bloody or black, tarry stools, vomiting blood or something that looks like coffee grounds
  • Chest pain that may spread, trouble breathing, unusual sweating, fainting
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Blurred vision or other vision changes
  • Constipation, gas, stomach pain
  • Headache or drowsiness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 12/4/2014


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