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Cyclobenzaprine (By mouth)

Cyclobenzaprine (sye-kloe-BEN-za-preen)

Treats pain and stiffness caused by muscle spasms.

Brand Name(s):

Amrix, Cyclobenzaprine Comfort Pac, Fexmid, FusePaq Tabradol, Therabenzaprine-60, Therabenzaprine-90, Therabenzaprine-90-5

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to cyclobenzaprine, or if you have an overactive thyroid, heart rhythm problems, heart failure, or you had a recent heart attack.

How to Use This Medicine:

Long Acting Capsule, Liquid, Tablet

  • Take your medicine as directed.
  • Swallow the extended-release capsule whole. Do not crush, break, or chew it.
  • Take this medicine at the same time each day.
  • This medicine is not for long-term use.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use this medicine if you have used an MAO inhibitor (MAOI) within the past 14 days.
  • Some medicines can affect how this medicine works. Tell your doctor if you are taking any of the following:
    • Bupropion
    • Depression medicine
    • Guanethidine
    • Meperidine, tramadol
    • Verapamil
  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have liver problems, or a history of glaucoma or problems with urination.
  • This medicine may cause a serious condition called serotonin syndrome, when taken with certain medicines. Ask your doctor for more information on serotonin syndrome.
  • This medicine may make you dizzy or drowsy. Do not drive or doing anything that could be dangerous until you know how this medicine affects you.
  • Call your doctor if your symptoms do not improve or if they get worse.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Anxiety, restlessness, fever, sweating, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there
  • Fast, pounding, or uneven heartbeat
  • Seizures or tremors
  • Severe drowsiness, fainting, or confusion
  • Trouble urinating

If you notice these less serious side effects, talk with your doctor:

  • Dry mouth
  • Headache or dizziness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 12/4/2014


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