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Cyclobenzaprine (By mouth)

Cyclobenzaprine (sye-kloe-BEN-za-preen)

Treats pain and stiffness caused by muscle spasms.

Brand Name(s):

Amrix, Cyclobenzaprine Comfort Pac, Fexmid, FusePaq Tabradol, Therabenzaprine-60, Therabenzaprine-90, Therabenzaprine-90-5

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to cyclobenzaprine, or if you have an overactive thyroid, heart rhythm problems, heart failure, or a recent heart attack. Do not use this medicine if you have used an MAO inhibitor (MAOI) such as Eldepryl®, Marplan®, Nardil®, or Parnate® within the past 14 days.

How to Use This Medicine:

Long Acting Capsule, Liquid, Tablet

  • Take your medicine as directed.
  • Swallow the extended-release capsule whole. Do not crush, break, or chew it.
  • Take this medicine at the same time each day.
  • This medicine is not for long-term use.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using guanethidine (Ismelin®), meperidine (Demerol®), tramadol (Ultracet®, Ultram®), verapamil (Calan®), or medicine to treat depression (such as amitriptyline, bupropion, citalopram, fluoxetine, imipramine, nortriptyline, sertraline, Cymbalta®, Effexor®, Elavil®, Lexapro®, Pristiq®, Wellbutrin®).
  • Tell your doctor if you are also using other medicines that can cause dry mouth or constipation such as atropine, dicyclomine, glycopyrrolate, scopolamine, Bentyl®, Robinul®, or Transderm Scop®.
  • Alcohol, narcotic pain relievers, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when used with this medicine. Tell your doctor if you drink alcohol or use pain relievers or sleeping pills.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have liver problems, or a history of glaucoma or problems with urination.
  • This medicine may cause a serious condition called serotonin syndrome, when taken with certain medicines. Call your doctor right away if you have a fever, confusion, mental changes, restlessness, fast heartbeat, muscle spasms, trouble walking, nausea, vomiting, or diarrhea.
  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous until you know how this medicine affects you.
  • Call your doctor if your symptoms do not improve or if they get worse.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Anxiety, restlessness, fever, sweating, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there
  • Fast, pounding, or uneven heartbeat
  • Seizures or tremors
  • Severe drowsiness, fainting, or confusion
  • Trouble urinating

If you notice these less serious side effects, talk with your doctor:

  • Dry mouth
  • Headache or dizziness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 7/4/2014


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