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Nystatin (Vaginal)

Nystatin (nye-STAT-in)

Treats vaginal yeast infections. Belongs to a class of drugs called antifungals.

Brand Name(s):

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had a previous allergic reaction to nystatin.

How to Use This Medicine:

Cream, Suppository

  • Your doctor will tell you how much medicine to use and how often.
  • Wash your hands before and after using this medicine.
  • The cream is in a tube. You will use an applicator to put the cream into your vagina.
  • The applicator is an empty plastic tube called a barrel that is open at one end and has a plunger (another piece of plastic that can move inside the barrel) at the other end.
  • Remove the cap from the end of the tube of cream. Squeeze the cream from the tube into the open end of the applicator until the barrel is filled with cream.
  • If you are using the vaginal tablets, unwrap the tablet and place it in the applicator with the pointed side up. You may wet the tablet with warm water or a water-soluble lubricating gel (K-Y® Jelly). You should not use petroleum jelly (Vaseline®).
  • Put the applicator into the vagina (like you would a tampon) as far as you can and push the plunger all the way in.
  • Remove the applicator and wash it with warm soapy water.
  • Wear only clean cotton underwear (panties) instead of nylon or rayon underwear. The medicine will come out of your vagina, so wear a minipad or sanitary napkin to protect your clothing. Keep using this medicine for as long as your doctor tells you to. Continue to use it even if your menstrual period begins. Use pads rather than tampons.

If a dose is missed:

  • Insert the missed dose as soon as possible unless it is almost time for next dose.
  • If it is almost time for your next regular dose, wait until then to use your medicine and skip the missed dose.
  • You should not use two doses at the same time.

How to Store and Dispose of This Medicine:

  • Store at room temperature in a closed container away from heat, moisture, and direct light. Store the cream away from heat. Do not freeze.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows before you use any other vaginal product (prescription or nonprescription).

Warnings While Using This Medicine:

  • Do not douche or have sex while using this medicine.
  • If you are pregnant or breastfeeding, talk with your doctor before using nystatin.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Symptoms get worse or do not improve

If you notice these less serious side effects, talk with your doctor:

  • Vaginal discharge

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 9/4/2014


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