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Primidone (By mouth)

Primidone (PRIM-i-done)

Treats seizure disorders. Belongs to a class of drugs called anticonvulsants.

Brand Name(s):

Mysoline

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to primidone, or to any kind of barbiturate medicine such as phenobarbital (Luminal®). You should not use this medicine if you have an enzyme problem called porphyria.

How to Use This Medicine:

Liquid, Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. .
  • It is best to take this medicine with food or milk.
  • Shake the oral liquid well before each dose. Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.
  • This medicine may be used with other seizure medicines. Keep using all of your seizure medicines unless your doctor tells you to stop.
  • It is best to plan your doses so they are evenly spaced during the day. Talk with your doctor if you have questions about when to take this medicine.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Do not freeze.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not drink alcohol while you are using this medicine.
  • Make sure your doctor knows if you are taking birth control pills.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you have kidney disease, liver disease, or a history of depression.
  • It is important to tell your doctor if you become pregnant while using this medicine. Your doctor may want you to join a pregnancy registry for patients taking a seizure medicine.
  • Do not breastfeed while you are using this medicine.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • For some children, teenagers, and young adults, this medicine can increase thoughts of suicide. Tell your doctor or your child's doctor right away if you or your child start to feel more depressed and have thoughts about hurting yourselves. Report any unusual thoughts or behaviors that trouble you or your child, especially if they are new or get worse quickly. Make sure the doctor knows if you or your child have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. Also tell the doctor if you or your child have sudden or strong feelings, such as feeling nervous, angry, restless, violent, or scared. Let the doctor know if you, your child, or anyone in your family has bipolar disorder (manic-depressive) or has tried to commit suicide.
  • This medicine may cause drowsiness. Be careful when driving, using dangerous machinery, or doing anything else that could be dangerous if you are not alert.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Fever, chills, sore throat, or pale skin.
  • Loss of coordination.
  • Loss of seizure control.
  • Problems with balance or walking.
  • Severe skin rash.
  • Unexplained fever.
  • Unusual behavior or thoughts of hurting yourself.
  • Unusual bleeding, bruising, or weakness.

If you notice these less serious side effects, talk with your doctor:

  • Blurred or double vision.
  • Drowsiness or dizziness.
  • Feeling of constant movement of self or surroundings.
  • Feeling irritable.
  • Nausea, vomiting, or loss of appetite.
  • Problems with sex.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 9/4/2014


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