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Rifampin/isoniazid (By mouth)

Isoniazid (eye-soe-NYE-a-zid), Rifampin (rif-AM-pin)

Treats tuberculosis (TB).

Brand Name(s):

Rifamate

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have ever had an allergic reaction to rifampin or isoniazid. Avoid using this medicine if you have liver disease.

How to Use This Medicine:

Capsule, Tablet

  • Take your medicine as directed.
  • Rifampin/isoniazid should be taken on an empty stomach, 1 hour before or 2 hours after a meal.
  • It is important to take this medicine on a regular schedule. Keep taking it even if you are feeling better. Your doctor will tell you when you can stop taking it.

If a dose is missed:

  • Take the missed dose as soon as possible.
  • If it is almost time for your next regular dose, wait until then to take your medicine and skip the missed dose.
  • You should not use two doses at the same time.

How to Store and Dispose of This Medicine:

  • Store at room temperature in a closed container, away from heat, light, and moisture.
  • Keep all medicine out of the reach of children.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not drink alcohol while taking this medicine.
  • Rifampin interacts with many other medicines. Make sure your doctor knows all of the medicines that you are taking before taking rifampin. The doses of the other medicines may have to be changed while you are taking rifampin.
  • Some types of fish and cheese may cause reactions such as flushing, chills, headache, slow or pounding heartbeat, and nausea and vomiting.
  • Birth control pills may not work if you take them with this medicine. A different kind of birth control should be used; check with your doctor.

Warnings While Using This Medicine:

  • If you are pregnant or breastfeeding, talk to your doctor before taking this medicine.
  • Be sure to see your doctor regularly while you are taking this medicine. Reschedule any appointments you miss.
  • Do not stop taking this medicine without talking to your doctor.
  • Your urine, stool, saliva (spit), sweat, and tears may turn a red-orange color when you take this medicine.
  • Soft contact lenses may be permanently stained by rifampin. You may not want to wear them while taking this medicine.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Nausea and vomiting with extreme tiredness
  • Yellowing of skin or eyes
  • Hives or severe skin rash
  • Fever
  • Numbness, pain, or tingling in arms or legs
  • Unsteadiness or weakness
  • Blurred vision or eye pain
  • Bloody or very dark urine

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea
  • Stomach upset or cramping
  • Loss of appetite

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 11/4/2014


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