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Trimipramine (By mouth)

Trimipramine (trye-MIP-ra-meen)

Treats depression. This medicine is a tricyclic antidepressant (TCA).

Brand Name(s):

Surmontil

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to trimipramine or similar medicines (such as desipramine, doxepin, Norpramin®, Pamelor®). Do not use this medicine if you have recently had a heart attack. Do not use this medicine and an MAO inhibitor (MAOI) such as Eldepryl®, Marplan®, Nardil®, Parnate®, methylene blue, or linezolid (Zyvox®) within 14 days of each other.

How to Use This Medicine:

Tablet, Capsule

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Your doctor may tell you to take this medicine at bedtime, because it can make you sleepy.
  • You may need to take this medicine for a month or longer before you feel better. If you feel that the medicine is not working well, do not take more than your normal dose. Call your doctor for instructions.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are taking buspirone (Buspar®), cimetidine (Tagamet®), fentanyl (Sublimaze®), guanethidine (Ismelin®), lithium (Eskalith®, Lithobid®), St John's wort, tryptophan supplements, pain or migraine medicines (such as eletriptan, sumatriptan, tramadol, Frova®, Maxalt®, Relpax®, Zomig®), thyroid medicine (such as levothyroxine, Levoxyl®, Synthroid®), medicine for heart rhythm problems (such as flecainide, propafenone, quinidine, Quinaglute®, Rythmol®, Tambocor®), other medicine to treat depression (such as fluoxetine, paroxetine, sertraline, Paxil®, Prozac®, Zoloft®), or a phenothiazine medicine (such as prochlorperazine, promethazine, Phenergan®, Thorazine®).
  • Tell your doctor if you are using atropine, dicyclomine (Bentyl®), glycopyrrolate (Robinul®), hyoscyamine (Cystospaz®), propantheline (Pro-Banthine®), or scopolamine (Transderm Scop®).
  • Tell your doctor if you drink alcohol or if you are using any medicine that makes you sleepy, such as allergy medicine or narcotic pain medicine.
  • Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, glaucoma, heart or blood vessel disease, schizophrenia, thyroid problems, or a history of mania, seizures, or trouble urinating.
  • For some children, teenagers, and young adults, this medicine can increase thoughts of suicide. Tell your doctor right away if you start to feel more depressed and have thoughts about hurting yourself. Report any unusual thoughts or behaviors that trouble you, especially if they are new or are getting worse quickly. Make sure the doctor knows if you have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. Also tell the doctor if you have sudden or strong feelings, such as feeling nervous, angry, restless, violent, or scared. Let the doctor know if you or anyone in your family has bipolar disorder (manic-depressive) or has tried to commit suicide.
  • This medicine may cause a serious condition called serotonin syndrome, when taken with certain medicines. Call your doctor right away if you have a fever, confusion, mental changes, restlessness, fast heartbeat, muscle spasms, trouble walking, nausea, vomiting, or diarrhea.
  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous until you know how this medicine affects you.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
  • This medicine could raise or lower your blood sugar level.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Agitation, restlessness, mood or mental changes, trouble sleeping
  • Anxiety, restlessness, fever, sweating, muscle spasms, nausea, vomiting, diarrhea, seeing or hearing things that are not there
  • Change in how much or how often you urinate, problems with urination
  • Chest pain, trouble breathing
  • Unusual behavior, thoughts of hurting yourself or others
  • Fast, slow, pounding, or uneven heartbeat
  • Increased hunger or thirst
  • Seizures

If you notice these less serious side effects, talk with your doctor:

  • Drowsiness or dizziness
  • Dry mouth

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 7/4/2014


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