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Oxycodone, rapid release (By mouth)

Oxycodone Hydrochloride (ox-i-KOE-done hye-droe-KLOR-ide)

Treats moderate to severe pain. Rapid-release oxycodone is a narcotic that is used for immediate pain relief.

Brand Name(s):

Eth-Oxydose, Oxecta, Oxy IR, Roxicodone

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to oxycodone, codeine, hydrocodone, dihydrocodeine, morphine, Tylenol® No. 3, Tylox®, or Vicodin®. You should not use this medicine if you have serious breathing problems (such as severe asthma or respiratory depression) or a serious bowel problem called paralytic ileus.

How to Use This Medicine:

Capsule, Liquid, Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • If this medicine upsets your stomach, it may be taken with food.
  • If you cannot swallow the extended-release capsule, you may open it and pour the medicine into a small amount of soft food such as pudding, yogurt, or applesauce. Stir this mixture well and swallow it without chewing.
  • Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.
  • Swallow the Oxecta(R) tablet whole with water. Do not break, crush, chew, or dissolve it. Do not pre-soak, lick, or wet the tablet before placing it in the mouth. Also, do not give this medicine through nasogastric or feeding tubes.
  • Drink plenty of liquids to help avoid constipation.
  • Use only the brand of medicine your doctor prescribed. Other brands may not work the same way.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Oxycodone can cause serious unwanted effects if taken by adults who are not used to strong narcotic pain medicines, children, or pets. Make sure you store the medicine in a safe and secure place to prevent others from getting it.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed. Flush the unused tablets down the toilet.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using buprenorphine (Buprenex®), butorphanol (Stadol®), nalbuphine (Nubain®), pentazocine (Talwin®), a phenothiazine medicine (such as chlorpromazine, prochlorperazine, promethazine, thioridazine, Compazine®, Phenergan®, Serentil®, or Thorazine®), or muscle relaxers (such as carisoprodol, cyclobenzaprine, metaxalone, methocarbamol, Skelaxin®, or Soma®). Tell your doctor if you have used an MAO inhibitor (such as Eldepryl®, Marplan®, Nardil®, or Parnate®) within the past 14 days.
  • Tell your doctor if you are also using medicine to treat an infection (such as clarithromycin, erythromycin, itraconazole, ketoconazole, voriconazole, Biaxin®, Ery-Tab®, Nizoral®, or Sporanox®), medicine to treat HIV/AIDS (such as atazanavir, indinavir, nelfinavir, ritonavir, saquinavir, Crixivan®, Fortovase®, Invirase®, Kaletra®, Norvir®, or Viracept®), medicine to treat seizures (such as carbamazepine, phenytoin, Dilantin®, or Tegretol®), or medicine to treat tuberculosis (such as rifampin, Rifadin®, or Rimactane®).
  • Do not drink alcohol while you are using this medicine.
  • Tell your doctor if you drink alcohol or if you are using any medicine that makes you sleepy, such as allergy medicine or narcotic pain medicine.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, lung disease or other breathing problems (such as chronic obstructive pulmonary disease [COPD], emphysema), kyphoscoliosis (curvature of the spine with breathing problems), heart disease, low blood pressure, problems with urination, an underactive thyroid, Addison's disease, gallbladder disease or gallstones, pancreas problems, prostate problems, or a stomach disorder. Tell your doctor if you have a history of head injury, brain tumor, depression, psychosis (a mental disease), seizures, or alcohol or drug abuse.
  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • Dizziness, lightheadedness, or fainting may occur when you get up suddenly from a lying or sitting position. Getting up slowly may help lessen this problem. Also, lying down for a while may relieve the dizziness or lightheadedness.
  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blue lips, fingernails, or skin.
  • Decrease in how much or how often you urinate.
  • Extreme weakness, shallow breathing, uneven heartbeat, sweating, or cold or clammy skin.
  • Lightheadedness, dizziness, or fainting.
  • Severe constipation or vomiting.

If you notice these less serious side effects, talk with your doctor:

  • Feelings of extreme happiness or sadness.
  • Headache.
  • Itching skin.
  • Lack or loss of strength.
  • Nausea, vomiting, or mild constipation.
  • Sleepiness or unusual drowsiness.
  • Trouble sleeping.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 8/4/2014


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