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Methylprednisolone (By mouth)

Methylprednisolone (meth-il-pred-NIS-oh-lone)

Treats asthma, allergic reactions, inflammation, flare-ups of ongoing illnesses, and many other medical problems. May also be used to lessen some symptoms of cancer. This medicine is a steroid.

Brand Name(s):

Medrol

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to methylprednisolone or if you have a fungus infection.

How to Use This Medicine:

Tablet

  • Take your medicine as directed.
  • If you are using this medicine for an ongoing illness, your dose may need to be changed occasionally. Some people take this medicine only every other day, which helps to decrease side effects.
  • Take your medicine in the morning, unless your doctor tells you otherwise.
  • It is best to take this medicine with food or milk.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using aspirin, cyclosporine (Sandimmune®, Neoral®), phenobarbital (Luminol®), phenytoin (Dilantin®), rifampin (Rifadin®), ketoconazole (Nizoral®), troleandomycin (TAO®), high-dose aspirin, a blood thinner such as warfarin (Coumadin®), or diabetes medicine (insulin or oral medicine such as Avandia®, Glucophage®).
  • This medicine may interfere with vaccines. Ask your doctor before you get a flu shot or any other vaccines.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have high blood pressure, blood clotting problems, tuberculosis, Strongyloides (threadworm) infection, thyroid problems, liver disease, mental or emotional problems, eye disease (especially herpes), stomach or digestive problems, osteoporosis, or myasthenia gravis.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • Avoid people who are sick or have infections, because you may get sick more easily. If you are exposed to chickenpox or measles, tell your doctor right away.
  • Tell your doctor if you have any events causing unusual stress or anxiety in your life. Your dose of this medicine may need to be changed.
  • Call your doctor if your symptoms do not improve or if they get worse.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Headache, eye pain, or trouble seeing.
  • Increased urination or thirst.
  • Muscle weakness or cramps.
  • Seizures, dizziness.
  • Stomach problems, stomach pain, bloody or black stools.
  • Sudden pain, swelling, or loss of movement in the lower leg.
  • Swelling in your hands, ankles, or feet, rapid weight gain.

If you notice these less serious side effects, talk with your doctor:

  • Mood changes, trouble sleeping, unusual behavior.
  • Redness in your face.
  • Weight gain, increased hair growth, roundness or swelling of your face, thinning skin.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 4/4/2014
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