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Fluvoxamine (By mouth)

Fluvoxamine (floo-VOX-a-meen)

Treats symptoms of obsessive-compulsive disorder (OCD). This medicine is a selective serotonin reuptake inhibitor (SSRI) antidepressant.

Brand Name(s):

Luvox CR

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to fluvoxamine. Do not use fluvoxamine if you are using alosetron (Lotronex®), pimozide (Orap®), ramelteon (Rozerem®), thioridazine (Mellaril®), or tizanidine (Zanaflex®). Do not use this medicine and an MAO inhibitor (MAOI) such as Eldepryl®, Marplan®, Nardil®, Parnate®, or linezolid (Zyvox®) within 14 days of each other.

How to Use This Medicine:

Long Acting Capsule, Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Take this medicine at bedtime, unless your doctor tells you otherwise.
  • Swallow the extended-release capsule whole. Do not crush, break, or chew it.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • There are many other drugs that can interact with fluvoxamine. Make sure your doctor knows about ALL other medicines you are using, especially medicines to treat depression or mental illness.
  • Make sure your doctor knows if you are also using other medicine to treat depression (such as amitriptyline, nortriptyline, desipramine, fluoxetine, mirtazapine, paroxetine, Celexa®, Elavil®, Lexapro®, Norpramin®, Paxil®, Zoloft®), medicine to treat migraine headaches (such as eletriptan, sumatriptan, tramadol, Frova®, Maxalt®, Relpax®, Zomig®), an NSAID pain or arthritis medicine (such as aspirin, diclofenac, ibuprofen, Advil®, Aleve®, Celebrex®, Voltaren®), or a blood thinner (such as warfarin, Coumadin®, Jantoven®).
  • Tell your doctor if you are also using buspirone (Buspar®), fentanyl (Sublimaze®), lithium (Eskalith®, Lithane®, Lithobid®), St John's wort, tryptophan supplements, or a diuretic (water pill, such as furosemide, hydrochlorothiazide, Lasix®).
  • Make sure your doctor knows if you also use a tranquilizer or sedative (such as alprazolam, Xanax®, diazepam, Valium®, midazolam, Versed®, or triazolam), blood pressure medicine (such as diltiazem, Cardizem®, atenolol, metoprolol, propranolol, Bystolic®, Tenormin®), clozapine (Clozaril®), methadone (Dolophine®), mexiletine (Mexitil®), theophylline (Theo-Dur®), omeprazole (Prilosec®), phenytoin (Dilantin®), tryptophan, tacrine (Cognex®), or carbamazepine (Tegretol®).
  • Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have liver disease, heart disease, bleeding problems, epilepsy or seizures, low sodium in the blood, a history of mania, or a recent heart attack. Tell your doctor if you smoke.
  • For some children, teenagers, and young adults, this medicine can increase thoughts of suicide. Tell your doctor right away if you start to feel more depressed and have thoughts about hurting yourself. Report any unusual thoughts or behaviors that trouble you, especially if they are new or are getting worse quickly. Make sure the doctor knows if you have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. Also tell the doctor if you have sudden or strong feelings, such as feeling nervous, angry, restless, violent, or scared. Let the doctor know if you or anyone in your family has bipolar disorder (manic-depressive) or has tried to commit suicide.
  • This medicine may cause a serious condition called serotonin syndrome, when taken with certain medicines. Call your doctor right away if you have a fever, confusion, mental changes, restlessness, fast heartbeat, muscle spasms, trouble walking, nausea, vomiting, or diarrhea.
  • Hyponatremia (low sodium in the blood) may occur with this medicine. Check with your doctor right away if you have confusion, difficulty concentrating, headaches, memory problems, weakness, and unsteadiness.
  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous until you know how this medicine affects you.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • This medicine may cause decreased appetite and weight loss. Your child's height and weight will be measured to make sure your child is growing properly.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Anxiety, restlessness, fever, sweating, muscle spasms, nausea, vomiting, diarrhea, seeing or hearing things that are not there
  • Confusion, weakness, and muscle twitching
  • Fast, pounding, or uneven heartbeat
  • Feeling more excited or energetic than usual
  • Headache, trouble concentrating, memory problems, unsteadiness
  • Seizures
  • Unusual behavior, thoughts of hurting yourself or others, panic
  • Unusual bleeding or bruising

If you notice these less serious side effects, talk with your doctor:

  • Nausea, diarrhea, constipation
  • Loss of appetite, weight loss
  • Dry mouth
  • Dizziness
  • Sexual problems
  • Sleepiness, tiredness, weakness
  • Sweating more than usual

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 10/4/2014


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