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Itraconazole (By mouth)

Itraconazole (it-ra-KON-a-zole)

Treats fungal infections. This is an antifungal medicine.

Brand Name(s):

Onmel, Sporanox

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to itraconazole. Do not use this medicine if you also use cisapride (Propulsid®), dofetilide (Tikosyn®), felodipine (Plendil®), levomethadyl (Orlaam®), methadone (Dolophine®), nisoldipine (Sular®), oral midazolam (Versed®), pimozide (Orap®), quinidine (Cardioquin®, Quinaglute®), triazolam (Halcion®), certain medicines to lower cholesterol (such as lovastatin, simvastatin, Mevacor®, Zocor®), or an ergot medicine (such as dihydroergotamine, ergonovine, ergotamine, methylergonovine, Cafergot®, Ergomar®, Wigraine®). Do not use this medicine if you have certain heart problems such as heart failure.

How to Use This Medicine:

Capsule, Liquid, Tablet

  • Take your medicine as directed.
  • Sporanox® oral liquid works differently than Sporanox® capsules, even at the same dose. Do not switch from the capsules to the oral liquid unless your doctor tells you to.
  • Take the capsule and tablet with a full meal. Take the oral liquid without food.
  • Take the tablets at the same time each day.
  • Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup. If you have thrush, swish the liquid in your mouth for several seconds and then swallow it.
  • Keep using this medicine for the full treatment time, even if your symptoms start to go away. It may take several weeks or months for your infection to clear up completely. If you have a nail infection, it may take even longer because it can take several months to grow new nails.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you use alfentanil (Alfenta®), amphotericin B (Fungizone®), buspirone (Buspar®), cilostazol (Pletal®), cyclosporine (Gengraf®, Neoral®, Sandimmune®), eletriptan (Relpax®), fentanyl (Sublimaze®), fexofenadine (Allegra®), halofantrine (Halfan®), loperamide (Imodium®), meloxicam (Mobic®), sirolimus (Rapamune®), tacrolimus (Prograf®), or cancer medicines (such as busulfan, docetaxel, vincristine, Myleran®, Oncovin®, Taxotere®, Vincasar®). Tell your doctor if you use a steroid medicine (such as budesonide, dexamethasone, fluticasone, methylprednisolone, Flonase®, Pulmicort®), stomach medicine (such as cimetidine, famotidine, lansoprazole, omeprazole, pantoprazole, ranitidine, Aciphex®, Dexilant®, Nexium®, Pepcid®, Prevacid®, Prilosec®, Tagamet®, Zantac®), or a blood thinner (such as warfarin, Coumadin®, Jantoven®).
  • Tell your doctor if you also use medicine to treat HIV/AIDS (such as efavirenz, indinavir, maraviroc, nevirapine, ritonavir, saquinavir, Crixivan®, Norvir®, Sustiva®), medicine to treat an infection (such as clarithromycin, erythromycin, isoniazid, rifabutin, rifampin, Biaxin®, Ery-tab®, Mycobutin®, Rifadin®, Rimactane®), medicine to lower cholesterol (such as atorvastatin, cerivastatin, Lipitor®), medicine for heart problems (such as digoxin, disopyramide, Lanoxin®, Norpace®), certain blood pressure medicines (such as amlodipine, diltiazem, nicardipine, nifedipine, verapamil, Cardene®, Cardizem®, Norvasc®), diabetes medicines that you take by mouth (such as glimepiride, glyburide, metformin, repaglinide, Actos®, Janumet®, Januvia®, Prandin®), medicine to treat seizures (such as carbamazepine, phenobarbital, phenytoin, Dilantin®, Luminal®, Tegretol®), or medicine for nerves or sleeping (such as alprazolam, diazepam, Xanax®).
  • If you use antacids (such as Maalox®, Mylanta®, Pepcid® Complete, Rolaids®, Tums®), take the antacid at least 1 hour before or 2 hours after the itraconazole.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, lung problems (such as asthma or COPD), any heart or heart rhythm problems, edema or body swelling, HIV infection or AIDS, or cystic fibrosis. Tell your doctor if you have had an allergic reaction to any other antifungal medicines such as fluconazole or ketoconazole.
  • Check with your doctor right away if you have rapid weight gain, trouble breathing, chest pain, extreme tiredness, uneven heartbeat, or body swelling. These may be symptoms of heart problems.
  • Rarely, this medicine may cause severe liver problems. Check with your doctor right away if you have yellow skin or eyes, dark urine, pale stools, nausea, vomiting, loss of appetite, or pain in the upper stomach. Tell your doctor if you have ever had liver problems caused by other medicines.
  • This medicine may cause neuropathy (nerve problems). Call your doctor right away if you have numbness or tingling in your hands or feet.
  • Temporary or permanent hearing loss may occur. Check with your doctor right away if you have any changes in your hearing.
  • Call your doctor if your symptoms do not improve or if they get worse.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Change in how much or how often you urinate
  • Chest pain, coughing up blood
  • Dark-colored urine or pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, yellow skin or eyes
  • Fast, pounding, or uneven heartbeat
  • Hearing loss
  • Lightheadedness, dizziness, or fainting
  • Numbness, tingling, or burning pain anywhere in your body
  • Rapid weight gain, swelling in your face, hands, ankles, or feet
  • Trouble breathing, cold sweats, and bluish-colored skin
  • Unusual tiredness or weakness

If you notice these less serious side effects, talk with your doctor:

  • Headache

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 10/4/2014


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