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Thioguanine (By mouth)

Thioguanine (thye-oh-GWA-neen)

Used with other medicines to treat certain kinds of leukemia.

Brand Name(s):

Tabloid

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if thioguanine or mercaptopurine (Purinethol®) have not been effective in treating your condition in the past.

How to Use This Medicine:

Tablet

  • Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
  • Take your medicine as directed.
  • Drink at least 6 to 8 large glasses of liquid every day while you are using this medicine.
  • If you vomit right after you take this medicine, call your doctor.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using mesalamine (Asacol®, Pentasa®), olsalazine (Dipentum®) or sulfasalazine (Azulfidine®).
  • Do not drink alcohol while you are using this medicine.
  • You should not use aspirin or any product that has aspirin in it (such as some cold medicines) unless you have talked to your doctor.
  • This medicine may interfere with vaccines. Ask your doctor before you get a flu shot or any other vaccines.

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Tell your doctor if you have gout, liver disease, or a history of kidney stones.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Avoid people who are ill, and wash your hands often. Brush and floss your teeth gently, do not play rough sports, and be careful with sharp objects.
  • This medicine may make your mouth sore and irritated. Use a soft-bristle toothbrush or mouth swab to brush your teeth.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Bloody or black, tarry stools.
  • Dark-colored urine or pale stools.
  • Fever, chills, cough, sore throat, and body aches.
  • Lightheadedness or fainting.
  • Nausea, vomiting, loss of appetite, pain in your upper stomach.
  • Pale skin, weakness.
  • Severe mouth sores that keep you from drinking liquids.
  • Stomach pain, especially on the right side of your stomach.
  • Unusual bruising or bleeding.
  • Yellowing of your skin or the whites of your eyes.

If you notice these less serious side effects, talk with your doctor:

  • Mild diarrhea.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 9/4/2014


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