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Cefotaxime (Injection)

Cefotaxime Sodium (sef-oh-TAX-eem SOE-dee-um)

Treats infections caused by bacteria. This medicine is a cephalosporin antibiotic.

Brand Name(s):

Amerinet Claforan, Claforan, Novaplus Claforan

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. You should not receive it if you had an allergic reaction to cefotaxime or any other cephalosporin antibiotic.

How to Use This Medicine:


  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot into a muscle or a vein.
  • A nurse or other health provider will give you this medicine.
  • Missed dose: You must use this medicine on a fixed schedule. Call your doctor or pharmacist if you miss a dose.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines can affect how cefotaxime works. Tell your doctor if you are using any of the following:
    • Furosemide, probenecid
    • Aminoglycoside antibiotic
    • NSAID pain or arthritis medicine, including aspirin, celecoxib, diclofenac, ibuprofen, naproxen

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease or a history of stomach or bowel disease (such as colitis). Tell your doctor if you had an allergic reaction to penicillin.
  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Call your doctor if your symptoms do not improve or if they get worse.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Fever, chills, cough, sore throat, and body aches
  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed
  • Severe diarrhea (watery or bloody), severe stomach pain, nausea or vomiting
  • Unusual bleeding, bruising, or weakness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 10/4/2015

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