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Erythromycin (Injection)

Erythromycin Lactobionate (e-rith-roe-MYE-sin lak-toe-BYE-oh-nate)

This medicine is a macrolide antibiotic used to treat bacterial infections. Also used to prevent heart infection and rheumatic fever in patients who have had an allergic reaction to penicillin or sulfa drugs.

Brand Name(s):

Erythrocin Lactobionate

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not receive this medicine if you have had an allergic reaction to erythromycin. Do not receive this medicine if you are also using astemizole or terfenadine.

How to Use This Medicine:

Injectable

  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
  • A nurse or other health provider will give you this medicine.
  • Your doctor may give you a few doses of this medicine until your condition improves and then switch you to an oral medicine that works the same way.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using alfentanil (Alfenta®), bromocriptine (Parlodel®), carbamazepine (Tegretol®), cyclosporine (Gengraf®, Neoral®, Sandimmune®), digoxin (Lanoxin®), hexobarbital (Citopan®), lovastatin (Altocor®, Mevacor®), phenytoin (Dilantin®), theophylline (Theo-Dur®), valproate (Depakote®), or a blood thinner (such as warfarin, Coumadin®).

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, or myasthenia gravis (severe muscle weakness).
  • Tell your doctor right away if you have dark urine or pale stools, yellow skin or eyes, nausea and vomiting, or upper stomach pain. These could be symptoms of a serious liver problem.
  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine. Diarrhea may occur 2 months or more after you stop using this medicine.
  • Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Call your doctor if your symptoms do not improve or if they get worse.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash
  • Dark-colored urine or pale stools
  • Diarrhea that may contain blood
  • Fast, pounding, or uneven heartbeat
  • Hearing loss
  • Nausea, vomiting, loss of appetite, or pain in your upper stomach
  • Severe muscle weakness
  • Yellowing of your skin or the whites of your eyes

If you notice these less serious side effects, talk with your doctor:

  • Mild diarrhea
  • Mild skin rash
  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 12/4/2014


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