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Metformin (By mouth)

Metformin Hydrochloride (met-FOR-min hye-droe-KLOR-ide)

Treats type 2 diabetes.

Brand Name(s):

Appformin, Appformin-D, Fortamet, Glucophage, Glucophage XR, Glumetza, Riomet

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use if you had an allergic reaction to metformin, or if you have severe kidney problems or metabolic acidosis.

How to Use This Medicine:

Liquid, Tablet, Long Acting Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • It is best to take this medicine with food or milk.
  • Swallow the extended-release tablet whole. Do not crush, break, or chew it. Tell your doctor if you have trouble swallowing the tablets whole.
  • Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines can affect how metformin works. Tell your doctor if you are using any of the following:
    • Acetazolamide
    • Dichlorphenamide
    • Diuretics (water pills)
    • Estrogen or birth control pills
    • Heart or blood pressure medicine
    • Isoniazid
    • Nicotinic acid
    • Phenothiazine medicine
    • Phenytoin
    • Steroid medicine
    • Thyroid medicine
    • Topiramate
    • Zonisamide

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have heart or blood vessel disease, heart failure, blood circulation problems, kidney disease, liver disease, anemia, an adrenal gland or pituitary gland disorder, or a vitamin B12 deficiency. Tell your doctor if you had a heart attack. Tell your doctor if you drink alcohol.
  • Too much of this medicine can cause a rare, but serious condition called lactic acidosis.
  • Part of the extended-release tablet may pass in your stool. This is normal.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine before you have surgery, an x-ray, CT scan, or other medical test.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Confusion, fast heartbeat, increased hunger, shakiness
  • Fever or chills
  • Stomach pain, nausea, vomiting, muscle pain or cramping
  • Trouble breathing, slow heartbeat, lightheadedness, dizziness
  • Unusual tiredness or weakness

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea, gas, nausea

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 9/4/2014


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