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Thalidomide (By mouth)

Thalidomide (tha-LID-oh-mide)

Treats and prevents erythema nodosum leprosum, a skin disease caused by leprosy. Also used in combination with dexamethasone to treat multiple myeloma.

Brand Name(s):

Thalomid

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use this medicine if you had an allergic reaction to thalidomide. This medicine can cause serious or life-threatening birth defects in unborn babies. Do not use this medicine if you are pregnant.

How to Use This Medicine:

Capsule

  • Take your medicine as directed.
  • Take this medicine with water, preferably at bedtime, and at least 1 hour after the evening meal.
  • Do not open the blister pack until you are ready to take the capsule. If you touch a broken capsule or the medicine in the capsule, wash your skin with soap and water right away.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: If you miss a dose or forget to use your medicine, use it as soon as you can. If you missed your dose more than 12 hours ago, then skip the missed dose and take your next dose at the regular time. Do not use extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Return any unused capsules to your doctor or pharmacist.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines can affect how thalidomide works. Tell your doctor if you are using St John's wort, amiodarone, bortezomib, carbamazepine, cimetidine, cisplatin, digoxin, disulfiram, docetaxel, famotidine, griseofulvin, lithium, metronidazole, modafinil, paclitaxel, phenytoin, rifabutin, rifampin, succinylcholine, vincristine, birth control pills, penicillin antibiotics, medicine to treat HIV infection, blood pressure medicines, or medicine to treat depression or mental illness.
  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

Warnings While Using This Medicine:

  • Use 2 forms of birth control beginning 4 weeks before you start treatment with this medicine. Continue to use birth control during treatment, even if the dose is stopped for a short time, and for at least 4 weeks after your last dose. Tell your doctor right away if you miss a period or think you might be pregnant. Pregnancy tests may be done weekly for the first month during treatment, and then every 2 to 4 weeks.
  • If you are a man who is sexually active, you must use a latex or synthetic condom every time you have sex with a woman who could get pregnant, even if you had a vasectomy. You must use condoms during treatment, even if the dose is stopped for a short time, and for at least 4 weeks after your last dose.
  • Do not donate blood or sperm while you take this medicine and for at least 4 weeks after your last dose.
  • Tell your doctor if you are breastfeeding, or if you have a history of seizures, heart attack, or stroke, bradycardia (slow heartbeat), or HIV infection.
  • This medicine may cause the following problems:
    • Increased risk for blood clots, heart attack, or stroke
    • Nerve damage, which may be permanent
    • Increased risk for infection
    • Increased risk for serious skin reactions
    • Tumor lysis syndrome
  • This medicine may cause you to feel dizzy, drowsy, or lightheaded. Do not drive or do anything that could be dangerous until you know how this medicine affects you. Stand or sit up slowly if you feel lightheaded.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Change in how much or how often you urinate, joint pain or swelling, lower back or side pain, swelling of the feet or lower legs
  • Chest pain, trouble breathing, or coughing up blood
  • Chest pain that may spread, nausea, unusual sweating, fainting
  • Fever, chills, cough, runny or stuffy nose, sore throat, and body aches
  • Lightheadedness, dizziness, drowsiness
  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet
  • Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking
  • Pain in your lower leg (calf)
  • Seizures or tremors
  • Slow, uneven, or fast, pounding heartbeat

If you notice these less serious side effects, talk with your doctor:

  • Anxiety, agitation, confusion
  • Constipation, loss of appetite, or weight changes
  • Headache
  • Mild skin rash or dry skin
  • Tiredness or weakness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 12/4/2014


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