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Tizanidine (By mouth)

Tizanidine (tye-ZAN-i-deen)

Treats muscle spasms. This medicine is a muscle relaxer.

Brand Name(s):

Comfort Pac w/Tizanidine, Zanaflex, Zanaflex Capsule

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to tizanidine, or if you are also using fluvoxamine (Luvox®) or ciprofloxacin (Cipro®).

How to Use This Medicine:

Capsule, Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • You may take this medicine with or without food, but you should take it the same way every time. Tizanidine works differently depending on whether you take it on an empty stomach or a full stomach. Talk to your doctor if you have any questions about this.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using medicine to lower blood pressure (such as clonidine, atenolol, hydrochlorothiazide [HCTZ], lisinopril, metoprolol, quinapril, Accupril®, Catapres®, Cozaar®, Diovan®, Lotrel®, Norvasc®, Toprol®, or Zestril®), medicine for heart rhythm problems (such as amiodarone, mexiletine, propafenone, verapamil, Cordarone®, Isoptin®, Mexitil®, or Rythmol®) or medicine to treat infection (such as ciprofloxacin, norfloxacin, Cipro®, or Noroxin®).
  • Make sure your doctor knows if you are also using acyclovir (Zovirax®), cimetidine (Tagamet®), famotidine (Pepcid®), fluvoxamine (Luvox®), ticlopidine (Ticlid®), zileuton (Zyflo®), or birth control pills.
  • Do not drink alcohol while you are using this medicine.
  • Tell your doctor if you drink alcohol or if you are using any medicine that makes you sleepy, such as allergy medicine or narcotic pain medicine.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have liver disease or kidney disease.
  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
  • To avoid dizziness from this medicine, stand up slowly from a sitting or lying position.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Change in how much or how often you urinate, painful urination.
  • Dark-colored urine or pale stools.
  • Dry mouth, sleepiness, or loss of strength.
  • Fever, chills, cough, sore throat, and body aches.
  • Hallucinations (seeing things that are not really there).
  • Jerky muscle movement you cannot control.
  • Lightheadedness, dizziness, or fainting.
  • Nausea, vomiting, loss of appetite, pain in your upper stomach.
  • Problems with speech.
  • Unusual bleeding, bruising, or weakness.
  • Unusually fast or slow heartbeat.
  • Yellowing of your skin or the whites of your eyes.

If you notice these less serious side effects, talk with your doctor:

  • Anxiety or depression.
  • Blurred vision.
  • Diarrhea, upset stomach.
  • Muscle stiffness, tremor.
  • Nervousness.
  • Unusual tiredness or weakness.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 4/4/2014
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