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Trandolapril/verapamil (By mouth)

Trandolapril (tran-DOE-la-pril), Verapamil Hydrochloride (ver-AP-a-mil hye-droe-KLOR-ide)

Treats high blood pressure. A lower blood pressure can reduce the risk of stroke and heart attack. This medicine contains an angiotensin-converting enzyme (ACE) inhibitor and a calcium channel blocker (CCB).

Brand Name(s):

Tarka

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to trandolapril or verapamil. Do not use this medicine if you are pregnant or have had angioedema (swelling of the face, arms, legs, or throat) that was caused by an ACE inhibitor. Do not use this medicine if you have low blood pressure or heart problems such as atrial fibrillation, heart block, sick sinus syndrome, or severe left ventricular dysfunction. Do not use this medicine together with aliskiren (Tekturna®) if you have diabetes.

How to Use This Medicine:

Long Acting Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • It is best to take this medicine with food or milk.
  • Carefully follow your doctor's instructions about any special diet.Drink plenty of fluids if you exercise, sweat more than usual, or have diarrhea or vomiting.
  • Swallow the extended-release tablet whole. Do not crush, break, or chew it.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Tell your doctor if you are also using a diuretic (water pill, such as amiloride, spironolactone, triamterene, Aldactone®) or other blood pressure medicine (such as aliskiren, amlodipine, atenolol, clonidine, hydrochlorothiazide (HCTZ), lisinopril, metoprolol, prazosin, propranolol, terazosin, timolol, Benicar®, Cozaar®, Diovan®).
  • Do not use this medicine together with aliskiren if you have diabetes.
  • Make sure your doctor knows if you are also using insulin or a diabetes medicine that you take by mouth (such as glimepiride, glyburide, metformin, Actos®, Janumet®, Januvia®), medicine to lower cholesterol (such as atorvastatin, lovastatin, simvastatin, Crestor®, Lipitor®, Vytorin®), or an NSAID pain or arthritis medicine (such as aspirin, diclofenac, ibuprofen, naproxen, Advil®, Aleve®, Celebrex®, Voltaren®).
  • Make sure your doctor knows if you are also using rifampin (Rifadin®), ritonavir (Norvir®), gold injections, medicine for heart rhythm problems (such as disopyramide, flecainide, quinidine, Norpace®, Tambocor®), medicine to treat an infection (such as clarithromycin, erythromycin, telithromycin, Ery-Tab®), or a medicine that suppresses your immune system (such as cyclosporine, sirolimus, tacrolimus, Gengraf®, Neoral®, Sandimmune®).
  • Make sure your doctor knows if you are taking carbamazepine (Tegretol®), digoxin (Lanoxin®), imipramine (Tofranil®), lithium (Eskalith®, Lithobid®), midazolam (Versed®), phenobarbital (Luminal®), or theophylline (Theo-Dur®). Tell your doctor if you are also using St John's wort, almotriptan (Axert®), buspirone (Buspar®), colchicine (Colcrys®), doxorubicin (Adriamycin®), or sulfinpyrazone (Anturane®).
  • Ask your doctor before you use any medicine, supplement, or salt substitute that contains potassium.

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Make sure your doctor knows if you are breastfeeding, or if you have kidney problems, liver disease, heart disease, congestive heart failure, diabetes, heart rhythm problems (such as PR interval prolongation), or a mineral imbalance (such as high or low potassium or sodium in your blood). Tell your doctor if you have a collagen vascular disease (such as lupus or scleroderma) or muscle problems (such as Duchenne muscular dystrophy).
  • This medicine could lower your blood pressure too much and cause you to feel dizzy or lightheaded. Stand or sit up slowly if you are dizzy. This is more likely to happen when you begin to use the medicine or if you become dehydrated.
  • Tell your doctor right away if you have upper stomach pain, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem.
  • Tell your doctor if you have a fever, chills, or sore throat. These could be symptoms of an infection caused by low numbers of white blood cells.
  • Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Do not stop using this medicine without asking your doctor, even if you feel well. This medicine will not cure your high blood pressure, but it will help keep it in the normal range. You may have to take blood pressure medicine for the rest of your life.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Chest pain (may be related to your disease and not a side effect)
  • Confusion, weakness, numbness or tingling in your hands, feet, or lips
  • Dark-colored urine or pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, yellow skin or eyes
  • Fast, slow, pounding, or uneven heartbeat
  • Fever, chills, sore throat, and body aches
  • Lightheadedness, dizziness, fainting
  • Trouble breathing, cold sweat, bluish-colored skin

If you notice these less serious side effects, talk with your doctor:

  • Dry cough

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 7/4/2014


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