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Losartan/hydrochlorothiazide (By mouth)

Hydrochlorothiazide (hye-droe-klor-oh-THYE-a-zide), Losartan Potassium (loe-SAR-tan poe-TAS-ee-um)

Treats high blood pressure. A lower blood pressure can reduce the risk of stroke and heart attack. This medicine is a combination of an angiotensin receptor blocker (ARB) and a diuretic (water pill).

Brand Name(s):

Hyzaar

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to losartan, hydrochlorothiazide, or a sulfonamide (sulfa drug). Do not use this medicine if you are pregnant or you are not able to urinate. Do not use this medicine together with aliskiren (Tekturna®) if you have diabetes or severe kidney disease.

How to Use This Medicine:

Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Carefully follow your doctor's instructions about any special diet. Drink plenty of fluids if you exercise, sweat more than usual, or have diarrhea or vomiting.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you also use other blood pressure medicines (such as aliskiren, candesartan, enalapril, lisinopril, losartan, olmesartan, valsartan, Accupril®, Avapro®, Cozaar®, Lotrel®, Zestril®) or diuretics or water pills (such as amiloride, furosemide, metolazone, spironolactone, triamterene, Aldactone®, Demadex®, Lasix®, Lozol®, Maxzide®, Midamor®, Zaroxolyn®).
  • Make sure your doctor knows if you also use adrenocorticotropic hormone (ACTH), fluconazole (Diflucan®), glycyrrhizin (found in licorice), lithium (Eskalith®, Lithobid®), norepinephrine, rifampin (Rifadin®, Rimactane®), medicine to lower cholesterol (such as cholestyramine, colestipol, Colestid®, Questran®), insulin or diabetes medicine that you take by mouth (such as glimepiride, glyburide, metformin, Actos®, Janumet®, Januvia®), or a steroid medicine (such as dexamethasone, prednisolone, prednisone, Medrol®). Tell your doctor if you also use an NSAID pain or arthritis medicine such as aspirin, diclofenac, ibuprofen, indomethacin, naproxen, Advil®, Aleve®, Celebrex®, Voltaren®.
  • Ask your doctor before you use medicines, supplements, or salt substitutes that contain potassium.
  • Alcohol, narcotic pain relievers, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when used with this medicine. Tell your doctor if you drink alcohol or use pain relievers or sleeping pills.

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Make sure your doctor knows if you are breastfeeding, or if you have kidney problems, liver disease (including cirrhosis), asthma, allergies, congestive heart failure, diabetes, gout, high cholesterol, or lupus. Tell your doctor if you have a mineral imbalance (such as high or low calcium, potassium, magnesium, or sodium in the blood). Tell your doctor if you have had angioedema that was caused by a blood pressure medicine.
  • This medicine could lower your blood pressure too much and cause you to feel dizzy or lightheaded. This is more likely to happen when you begin to use the medicine or if you become dehydrated. Stand or sit up slowly if you are dizzy.
  • Check with your doctor immediately if you have blurred vision, trouble seeing, eye pain, or any other change in vision. These could be symptoms of glaucoma, which could cause permanent damage to your vision.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Do not stop using this medicine without asking your doctor, even if you feel well. This medicine will not cure your high blood pressure, but it will help keep it in normal range. You may have to take blood pressure medicine for the rest of your life.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blood in the urine, lower back or side pain
  • Change in vision, eye pain
  • Confusion, weakness, trouble breathing, numbness or tingling in your hands, feet, or lips
  • Decrease in how much or how often you urinate
  • Dry mouth, increased thirst, muscle pain or cramps
  • Fast, pounding, or uneven heartbeat
  • Lightheadedness, dizziness, or fainting
  • Loss of appetite, pain in your upper stomach, yellow skin or eyes
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Seizures
  • Severe nausea or vomiting

If you notice these less serious side effects, talk with your doctor:

  • Dry cough, runny or stuffy nose, sore throat

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 9/4/2014


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