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Ibuprofen/hydrocodone (By mouth)

Hydrocodone Bitartrate (hye-droe-KOE-done bye-TAR-trate), Ibuprofen (eye-bue-PROE-fen)

Treats pain. This medicine contains a narcotic pain reliever and an NSAID.

Brand Name(s):

Ibudone, Reprexain, Vicoprofen

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to hydrocodone, ibuprofen, or to other pain medicines such as aspirin, Aleve®, Celebrex®, Darvon®, Motrin®, Percocet®, or Vicodin®. You should not use this medicine if you have an asthma attack, stomach ulcer, or a bleeding disorder. Do not use this medicine right before or right after having coronary artery bypass surgery (CABG), a type of heart surgery.

How to Use This Medicine:

Tablet

  • Take your medicine as directed.
  • Do not use this medicine for longer than 10 days, unless your doctor tells you to.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Drink plenty of liquids to help avoid constipation.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Tell your doctor if you are also using dicyclomine (Bentyl®), ipratropium (Atrovent®), orphenadrine (Flexor®, Norflex®), oxybutynin (Ditropan®), scopolamine (Transderm-Scop®), tolterodine (Detrol®), or trospium (Sanctura®). Make sure your doctor knows if you use a blood thinner (such as warfarin, Coumadin®), or a steroid medicine (such as cortisone, dexamethasone, hydrocortisone, methylprednisolone, prednisolone, prednisone, or Orapred®).
  • Make sure your doctor knows if you are also using lithium (Eskalith®), methotrexate (Folex®, Trexall®), a diuretic or "water pill" (such as furosemide, hydrochlorothiazide [HCTZ], torsemide, Demadex®, or Lasix®), or a blood pressure medicine (such as captopril, enalapril, lisinopril, Accupril®, Lotrel®, Prinivil®, or Zestril®). Make sure your doctor knows if you are using a medicine for depression such as amitriptyline, doxepin, nortriptyline, selegiline, tranylcypromine, Elavil®, Eldepryl®, Pamelor®, Parnate®, or Sinequan®.
  • Do not use any other NSAID medicine unless your doctor says it is okay. Some other names are aspirin, diclofenac, naproxen, Advil®, Aleve®, Celebrex®, Ecotrin®, Motrin®, or Voltaren®.
  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.
  • Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding. Do not use this medicine during late pregnancy or while you are breastfeeding, unless your doctor tells you to.
  • Make sure your doctor knows if you have kidney disease, liver disease, asthma, lung disease, lupus, Addison's disease, an underactive thyroid, high blood pressure, congestive heart failure (CHF), or other heart or circulation problems. Tell your doctor if you have a bladder obstruction or a prostate disorder, stomach or intestinal disorders, or if you have ever had an ulcer, seizures, or a head injury.
  • This medicine might cause bleeding in your stomach or intestines. These problems can happen without warning signs. This is more likely if you have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, if you are over 60 years old, if you are in poor health, or if you are using certain other medicines (a steroid medicine or a blood thinner).
  • This medicine may raise your risk of having a heart attack or stroke. This is more likely in people who already have heart disease. People who use this medicine for a long time might also have a higher risk.
  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash.
  • Bloody or black, tarry stools.
  • Change in how much or how often you urinate.
  • Chest pain, shortness of breath, or coughing up blood.
  • Dark-colored urine or pale stools.
  • Fast heartbeat, warmth or redness in your face or neck.
  • Fever, chills, or sore throat.
  • Flu-like symptoms.
  • Numbness or weakness in your arm or leg, or on one side of your body.
  • Pain in your lower leg (calf).
  • Problems with vision, speech, or walking.
  • Rapid weight gain.
  • Severe stomach pain.
  • Shortness of breath, cold sweat, and bluish-colored skin.
  • Skin rash or blisters with fever.
  • Sudden or severe headache.
  • Swelling in your hands, ankles, or feet.
  • Vomiting blood or something that looks like coffee grounds.
  • Yellowing of your skin or the whites of your eyes.

If you notice these less serious side effects, talk with your doctor:

  • Constipation, diarrhea, or gas.
  • Headache, nervousness, or anxiety.
  • Increased sweating.
  • Mild nausea, vomiting, upset stomach, or stomach pain.
  • Mild skin itching.
  • Ringing in your ears.
  • Unusual weakness, sleepiness, or trouble sleeping.
  • Vision changes.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 12/4/2014


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