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Epirubicin (Injection)

Epirubicin Hydrochloride (ep-i-ROO-bi-sin hye-droe-KLOR-ide)

Used with other cancer medicines to treat breast cancer.

Brand Name(s):

Ellence, Novaplus Epirubicin Hydrochloride

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not receive this medicine if you have had an allergic reaction to epirubicin, doxorubicin, daunorubicin, idarubicin, or mitoxantrone. Do not receive this medicine if you are pregnant, or if you have severe liver disease, severe heart disease, heart rhythm problems (such as arrhythmia), or a recent heart attack.

How to Use This Medicine:

Injectable

  • Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
  • You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
  • This medicine must be given slowly, so the IV tube must remain in place for at least 15 to 20 minutes. It is usually given every 3 to 4 weeks.
  • You may also receive other medicines to help prevent allergic reactions and nausea or vomiting from epirubicin.
  • Drink extra fluids so you will urinate more often and help prevent kidney problems.

If a dose is missed:

  • This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using cimetidine (Tagamet®), trastuzumab (Herceptin®), or certain blood pressure medicines (such as diltiazem, nifedipine, verapamil, Cardizem®, Norvasc®, or Verelan®). Tell your doctor if you are also using certain cancer medicines (such as docetaxel, paclitaxel, Taxol®, or Taxotere®) or a radiation treatment.
  • This medicine may interfere with vaccines. Ask your doctor before you get a flu shot or any other vaccines.

Warnings While Using This Medicine:

  • This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant.
  • Make sure your doctor knows if you are breastfeeding, or if you have kidney disease, liver disease, congestive heart failure, gout, or any type of infection.
  • Your doctor may monitor your heart before you start receiving epirubicin and while you are getting treatments with this medicine. Call your doctor right away if you have any chest pain, increased coughing, trouble with breathing, a sudden difficulty with breathing at night, rapid weight gain, or abnormal swelling in your ankles or legs. These could be symptoms of serious heart problems.
  • This medicine can rarely cause leukemia (cancer of the blood). Talk with your doctor if you have concerns about this.
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
  • If epirubicin accidentally leaks out of the vein into which it is injected, it may damage some tissues and may cause scarring. Tell the doctor right away if you notice redness, pain, or swelling at the injection site.
  • This medicine may cause a serious type of reaction called tumor lysis syndrome. Your doctor may give you a medicine to help prevent this. Call your doctor right away if you have a decrease or change in urine amount; joint pain, stiffness, or swelling; lower back, side, or stomach pain; a rapid weight gain; swelling of the feet or lower legs; or unusual tiredness or weakness.
  • This medicine may turn your urine red for 1 or 2 days after your treatment. This is normal and is nothing to worry about. You may want to protect your clothing from being stained.
  • Cancer medicines can cause nausea and/or vomiting in most people, sometimes even after receiving medicines to prevent it. Ask your doctor or nurse about other ways to control these side effects.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Fast, slow, or uneven heartbeat.
  • Fever, chills, cough, sore throat, and body aches.
  • Pain, itching, burning, redness, swelling, or a lump under your skin where the needle is placed.
  • Painful mouth sores that keep you from drinking liquids.
  • Shortness of breath, cold sweat, and bluish-colored skin.
  • Swelling in your hands, ankles, or feet.
  • Unusual bleeding, bruising, or weakness.

If you notice these less serious side effects, talk with your doctor:

  • Burning, dry, or itching eyes.
  • Changes in menstrual periods.
  • Diarrhea, nausea, vomiting, or loss of appetite.
  • Hair loss.
  • Rash or itching skin.
  • Unusual drowsiness, dullness, tiredness, or feeling of sluggishness.
  • Warmth or redness in your face, neck, arms, or upper chest.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 11/4/2014


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