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Denileukin diftitox (Injection)

Denileukin Diftitox (den-i-LOO-kin DIF-ti-tox)

Treats cutaneous T-cell lymphoma.

Brand Name(s):

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. You should not receive it if you had an allergic reaction to denileukin diftitox, diphtheria toxin, or interleukin-2.

How to Use This Medicine:

Injectable

  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein. The medicine must be injected slowly, so the IV will remain in place for 30 to 60 minutes.
  • You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
  • Missed dose: This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have heart disease.
  • This medicine may cause the following problems:
    • Infusion reaction
    • Capillary leak syndrome
    • Vision changes
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Fever, chills, headache, nausea, vomiting, trouble breathing, fast heartbeat
  • Lightheadedness, dizziness, fainting
  • Rapid weight gain, swelling in the hands, arms, legs, or feet
  • Unusual tiredness or weakness
  • Vision changes

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea
  • Mild nausea or vomiting, loss of appetite
  • Muscle pain or stiffness
  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed
  • Rash, itching

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 8/4/2014


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