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Meloxicam (By mouth)

Meloxicam (mel-OX-i-kam)

Treats symptoms of osteoarthritis (OA) and rheumatoid arthritis (RA). This medicine is a nonsteroidal anti-inflammatory drug (NSAID).

Brand Name(s):

Comfort Pac with Meloxicam, Mobic, Trepoxicam-7.5

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to meloxicam. Do not use this medicine if aspirin or other NSAID medicines (such as aspirin, diclofenac, ibuprofen, naproxen, Advil®, Aleve®, Celebrex®, Voltaren®) have ever caused you to have breathing problems, runny nose, hives, or other allergy-type problems. Do not use this medicine right before or right after coronary artery bypass graft (CABG) surgery.

How to Use This Medicine:

Liquid, Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • You may take this medicine with or without food.If this medicine upsets your stomach, take it with food or milk.
  • Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.Shake the bottle gently before use.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Mobic® oral liquid contains sorbitol, which may cause a very serious bowel problem when taken with sodium polystyrene sulfonate (Kayexalate®). Do not take the oral liquid together with Kayexalate®.
  • Make sure your doctor knows if you are also using aspirin, cholestyramine (Questran®), cyclosporine (Gengraf®, Neoral®, Sandimmune®), a blood thinner (such as warfarin, Coumadin®), or a steroid medicine (such as hydrocortisone, methylprednisolone, prednisolone, prednisone). Tell your doctor if you are using lithium (Eskalith®, Lithobid®), methotrexate (Rheumatrex®, Trexall®), a diuretic (water pill, such as furosemide, hydrochlorothiazide [HCTZ], torsemide, Demadex®, Lasix®), or certain blood pressure medicine (such as captopril, enalapril, lisinopril, losartan, Accupril®, Atacand®, Cozaar®, Diovan®, Lotrel®, Monopril®, Prinivil®, Zestoretic®, or Zestril®).
  • Do not use any other NSAID medicine unless your doctor says it is okay. Some other NSAIDs are aspirin, diclofenac, etodolac, ibuprofen, indomethacin, low-dose aspirin, naproxen, nabumetone, piroxicam, Advil®, Aleve®, Celebrex®, Feldene®, or Voltaren®.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding. Do not use this medicine during the later part of pregnancy, unless your doctor tells you to.
  • This medicine may cause a delay in ovulation for women and may temporarily affect their ability to have children. Talk with your doctor before you use this medicine if you are trying to get pregnant.
  • Make sure your doctor knows if you have a history of ulcers or other stomach problems. Tell your doctor if you have kidney disease, liver disease, anemia, or asthma.
  • Tell your doctor if you have heart, bleeding, or other circulation problems, such as high blood pressure or congestive heart failure (CHF).
  • This medicine may increase your risk of a heart attack or stroke. This is more likely with long-term use and in people who have heart and blood vessel disease. Tell your doctor right away if you have chest pain or discomfort, nausea or vomiting, pain or discomfort in your arms, jaw, back, or neck, shortness of breath, slurred speech, or weakness.
  • This medicine may cause bleeding in your stomach or intestines. This is more likely if you have ever had a stomach ulcer, smoke or drink alcohol regularly, are 60 years of age or older, are in poor health, or use certain medicine, such as a steroid or blood thinner.
  • Liver problems may occur while you are using this medicine. Stop using this medicine and tell your doctor right away if you have more than one of these symptoms: stomach pain or tenderness, clay-colored stools, dark urine, decreased appetite, fever, headache, itching, loss of appetite, nausea, vomiting, skin rash, swelling of the feet or lower legs, unusual tiredness or weakness, yellow eyes or skin.
  • Serious skin reactions can occur during treatment with this medicine. Tell your doctor right away if you have blistering, peeling, or loose skin, red skin lesions, skin rash, skin sores or ulcers, fever, or chills.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash
  • Bloody or black, tarry stools
  • Change in how much or how often you urinate, painful urination
  • Chest pain, trouble breathing, coughing up blood
  • Dark-colored urine or pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, yellow skin or eyes
  • Flu-like symptoms
  • Numbness or weakness in your arm or leg, or on one side of your body
  • Pain in your lower leg (calf)
  • Rapid weight gain
  • Severe stomach pain
  • Sudden or severe headache, problems with vision, speech, walking
  • Swelling in your hands, ankles, or feet
  • Unusual bleeding, bruising, or weakness
  • Vomiting of blood or something that looks like coffee grounds

If you notice these less serious side effects, talk with your doctor:

  • Mild nausea, diarrhea, heartburn, stomach upset

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 4/4/2014
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