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Linezolid (By mouth)

Linezolid (lin-AYZ-oh-lid)

Treats bacterial infections and certain types of skin infections or pneumonia. This medicine is an antibiotic.

Brand Name(s):

Zyvox

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to linezolid. Do not use this medicine if you have used an MAO inhibitor (MAOI) such as Eldepryl®, Marplan®, Nardil®, or Parnate® in the past 14 days.Unless your doctor monitors your condition, do not use this medicine if you have carcinoid syndrome or take medicine to treat depression (such as amitriptyline, doxepin, fluoxetine, nortriptyline, paroxetine, Celexa®, Effexor®, Elavil®, Lexapro?, Paxil®, or Zoloft®), medicine to treat migraine headaches (such as sumatriptan, zolmitriptan, Axert®, Imitrex®, or Zomig®), buspirone (Buspar®), or meperidine (Demerol®). Unless your doctor monitors your blood pressure, do not use this medicine if you have uncontrolled high blood pressure, pheochromocytoma, or thyroid problems. You will need your blood pressure monitored if you take linezolid while you use dobutamine (Dobutrex®), dopamine (Intropin®), or cold medicines or decongestants (such as phenylpropanolamine, pseudoephedrine, or Sudafed®).

How to Use This Medicine:

Liquid, Tablet

  • Take your medicine as directed.
  • If you are using the oral liquid, gently turn the bottle upside down 3 to 5 times before you pour your dose. Do not shake the bottle.Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.
  • Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. You may keep the oral liquid for up to 21 days. After that, throw away any unused medicine.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • You should not use this medicine if you have used an MAO inhibitor (MAOI) such as Eldepryl®, Marplan®, Nardil®, or Parnate® in the past 14 days. Tell your doctor if you use buspirone (Buspar®), dobutamine (Dobutrex®), dopamine (Intropin®), meperidine (Demerol®), cold medicines or decongestants (such as phenylpropanolamine, pseudoephedrine, or Sudafed®), medicine to treat depression (such as amitriptyline, doxepin, fluoxetine, nortriptyline, paroxetine, Celexa®, Effexor®, Elavil®, Lexapro?, Paxil®, or Zoloft®), or medicine to treat migraine headaches (such as sumatriptan, zolmitriptan, Axert®, Imitrex®, or Zomig®).
  • Avoid foods or drinks that contain tyramine. This includes aged cheeses, dried meats, sauerkraut, soy sauce, tap beers, or red wines.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have bone marrow problems, diabetes, or a history of high blood pressure or seizures.
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine. It may occur 2 months or more after you stop taking this medicine.
  • You may develop low blood sugar while you are using this medicine. You may feel weak, drowsy, confused, anxious, or very hungry. You may have trouble seeing or have a headache that won't go away. Ask your doctor what you should do if this happens.
  • This medicine may cause a serious reaction called lactic acidosis. Call your doctor right away if you feel very tired or weak, lightheaded or faint, have nausea or vomiting, or have trouble breathing.
  • This medicine may cause a serious condition called serotonin syndrome when taken with certain medicines. Check with your doctor first before you take any other medicines. Call your doctor right away if you have a fever, confusion, restlessness, loss of coordination, or diarrhea.
  • Check with your doctor right away if blurred vision or any other change in vision occurs. Your eyes may need to be checked by an eye doctor.
  • The oral liquid contains phenylalanine (aspartame). This is only a concern if you have phenylketonuria. If you have this condition, talk to your doctor before you use this medicine.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Call your doctor if your symptoms do not improve or if they get worse.
  • Use this medicine only if your doctor has prescribed it to treat a bacterial infection. This medicine will not treat viral infections such as the flu or the common cold.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there
  • Changes in vision
  • Diarrhea that may contain blood
  • Drowsiness or increased hunger
  • Extreme weakness, tiredness, or confusion
  • Fever, chills, cough, sore throat, and body aches
  • Lightheadedness or fainting
  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet
  • Rapid breathing, or severe nausea and vomiting
  • Seizures
  • Unusual bleeding or bruising

If you notice these less serious side effects, talk with your doctor:

  • Headache
  • Mild nausea, diarrhea, or vomiting

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 12/4/2014


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