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Amlodipine/benazepril (By mouth)

Amlodipine (am-LOE-di-peen), Benazepril (ben-AZ-e-pril)

Treats high blood pressure. This medicine contains an angiotensin-converting enzyme (ACE) inhibitor and a calcium channel blocker (CCB).

Brand Name(s):

Lotrel

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to amlodipine or benazepril, you are pregnant, or you have a history of angioedema.

How to Use This Medicine:

Capsule

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. Take this medicine at the same time each day.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
  • Missed dose: Take the medicine as soon as you can. If more than 12 hours have passed since you missed your last dose, skip the missed dose and take the next dose when you normally would.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use this medicine together with aliskiren if you have diabetes.
  • Some medicines and foods can affect how amlodipine/benazepril works. Tell your doctor if you are taking any of the following:
    • Diuretic medicine (water pill), such as amiloride, furosemide, hydrochlorothiazide, spironolactone, triamterene
    • HIV/AIDS medicine, such as indinavir, ritonavir
    • Infection medicine, such as clarithromycin, itraconazole, ketoconazole
    • Insulin or oral diabetes medicine, such as glimepiride, glyburide, metformin
    • Lithium
    • NSAID pain or arthritis medicine, such as aspirin, diclofenac, ibuprofen, naproxen
    • Simvastatin
  • Ask your doctor before you use any medicine, supplement, or salt substitute that contains potassium.

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Tell your doctor if you are breastfeeding, or if you have kidney problems, liver disease, heart failure, heart disease, low blood pressure, diabetes, or a mineral imbalance, such as high potassium or low sodium.
  • This medicine may cause the following problems:
    • Angioedema
    • Worsening symptoms of an existing heart problem
  • This medicine could lower your blood pressure too much, especially when you first use it or if you are dehydrated. Stand or sit up slowly if you feel lightheaded or dizzy.
  • Tell any doctor or dentist who treats you that you are taking this medicine. This medicine could affect surgery or other procedures that involve anesthetics.
  • Do not stop using this medicine without asking your doctor, even if you feel well. This medicine will not cure your high blood pressure, but it will help keep it in a normal range. You may have to take blood pressure medicine for the rest of your life.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Change in how much or how often you urinate
  • Chest pain that is worse than usual
  • Chest pain that spreads to your arms, jaw, back, or neck, trouble breathing, unusual sweating, or faintness
  • Confusion, weakness, trouble breathing, numbness or tingling in your hands, feet, or lips
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, yellow skin or eyes
  • Fast, pounding, or uneven heartbeat
  • Lightheadedness, dizziness, fainting
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Severe stomach pain
  • Unusual tiredness or weakness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 9/4/2014


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