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Dolasetron (Injection)

Dolasetron Mesylate (doe-LAS-e-tron MES-i-late)

Prevents and treats nausea and vomiting that may happen after surgery.

Brand Name(s):

Anzemet

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not receive this medicine if you have had an allergic reaction to dolasetron, or if you have a heart rhythm problem called congenital long QT syndrome.

How to Use This Medicine:

Injectable

  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein. It is usually given in your arm, wrist, hand, or sometimes in your chest.
  • For surgery, this medicine is usually given as a single dose before or after surgery.
  • A nurse or other health provider will give you this medicine.
  • Dolasetron may be mixed with juice and given by mouth to children.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also taking diuretics or "water pills", cimetidine (Tagamet®), rifampin (Rifadin®, Rifamate®, Rimactane®), or medicines to treat heart rhythm problems (such as flecainide, quinidine, verapamil Calan®, Cardioquin®, Isoptin®, Quinaglute®, Tambocor®, or Verelan®).
  • Make sure your doctor knows about all cancer medicines you may be receiving, especially drugs like doxorubicin (Adriamycin®) or daunorubicin (Cerubidine®).

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, congestive heart failure, heart disease, heart rhythm problems (such as prolonged QT, PR, and QRS interval), slow heartbeat, or low potassium or magnesium in the blood.
  • This medicine can cause changes in heart rhythms, such as conditions called QT, PR, and QRS prolongation. It may change the way your heart beats and cause fainting or serious side effects in some patients. Contact your doctor right away if you have any symptoms of heart rhythm problems, such as fast, pounding, or irregular heartbeats.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Fast, slow, pounding, or uneven heartbeat.
  • Lightheadedness, dizziness, or fainting.

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea.
  • Headache.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 7/4/2014


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