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Sumatriptan (Into the nose)

Sumatriptan (soo-ma-TRIP-tan)

Treats migraine headaches. This medicine does not prevent migraines. This medicine is a triptan.

Brand Name(s):

Imitrex

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to sumatriptan, or if you have heart disease, blood vessel disease, circulation problems, or severe liver disease. Tell your doctor if you have high blood pressure that is not under control, or a history of heart disease, heart attack, angina, stroke, transient ischemic attack (TIA), or ischemic bowel disease. You should not use this medicine for hemiplegic or basilar migraines. Do not use this medicine if in the past 2 weeks you have used an MAO inhibitor (MAOI, such as isocarboxazid, phenelzine, selegiline, tranylcypromine, Eldepryl®, Marplan®, Nardil®, or Parnate®). Do not use this medicine if you have taken another migraine headache medicine in the past 24 hours, such as another triptan or an ergot medicine. These medicines include dihydroergotamine (D.H.E. 45®, Migranal®), ergotamine (Cafergot®, Ergomar®, Wigraine®), Treximet®, almotriptan (Axert?), eletriptan (Relpax®), frovatriptan (Frova®), naratriptan (Amerge®), rizatriptan (Maxalt®), or zolmitriptan (Zomig®).

How to Use This Medicine:

Spray

  • Take your medicine as directed.
  • Use only 1 spray of medicine for 1 dose, unless your doctor or pharmacist tells you to use more.
  • This medicine is for use only in the nose. Do not get any of it in your eyes or on your skin. If it does get on these areas, rinse it off right away.
  • If your headache does not get any better after 1 dose of medicine, do not use another dose unless your doctor tells you to.
  • If your headache does not completely go away or comes back after 1 dose of medicine, wait at least 2 hours before you take another dose.
  • Talk with your doctor if you need to treat more than 4 headaches in any 30-day period.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

How to Store and Dispose of This Medicine:

  • Keep the bottle tightly closed when not using it. Store at room temperature, away from heat and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using medicine for depression, such as citalopram, duloxetine, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, trazodone, venlafaxine, Celexa®, Cymbalta®, Effexor®, Lexapro®, Luvox®, Paxil®, Prozac®, Sarafem®, Serzone®, Symbyax®, or Zoloft®.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant, or if you have kidney disease, liver disease, high blood pressure, diabetes, or epilepsy (seizures). Tell your doctor if you have a history of stomach or bowel bleeding, Raynaud disease, or other types of blood flow problems.
  • This medicine can cause heart problems, including heart attack. This is more likely to happen if you already have heart disease. Tell your doctor if you have any risk factors for heart disease, such as high blood pressure, high cholesterol, smoking, diabetes, or a family history of heart disease. Men over 40 years old, women who are past menopause, and people who are overweight are also more likely to have heart disease.
  • This medicine should be used only for classic or common migraine headaches. It will not work for any other kind of headache or pain.
  • Do not breastfeed for 12 hours after using this medicine.
  • This medicine may cause a serious condition called serotonin syndrome, when taken with certain medicines. Call your doctor right away if you have a fever, confusion, mental changes, restlessness, fast heartbeat, muscle spasms, trouble walking, nausea, vomiting, or diarrhea.
  • Do not use this medicine if your headache symptoms are different from your usual migraine headache. Call your doctor if your headache is unusual or severe. Call your doctor if your symptoms do not improve or if they get worse.
  • You could make your migraine headaches worse if you take migraine medicine too often (more than 10 days every month). Keep track of how often you have migraines and how much medicine you use.
  • This medicine may make you dizzy or drowsy. Do not drive, use machines, or do anything else that could be dangerous until you know how this medicine affects you.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there
  • Chest pain, especially if it spreads to your arms, jaw, back, or neck; trouble breathing; nausea; unusual sweating; faintness
  • Color changes and cold feeling in your toes or fingers
  • Fast, pounding, or uneven heartbeat
  • Numbness, tingling, cramps, unexplained pain in your legs or feet
  • Severe stomach pain, bloody diarrhea, vomiting, nausea, fever
  • Sudden severe headache (other than the one being treated)
  • Tightness or discomfort in your chest, neck, or jaw
  • Vision changes that are not part of a usual migraine

If you notice these less serious side effects, talk with your doctor:

  • Bad or unusual taste in your mouth
  • Burning or tingling in your nose
  • Drowsiness, tiredness, dizziness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 12/4/2014


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