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Hepatitis A/hepatitis B vaccine (Injection)

Hepatitis A Vaccine, Inactivated (hep-a-TYE-tis A VAX-een, in-AK-ti-vay-ted), Hepatitis B Vaccine Recombinant (hep-a-TYE-tis B VAX-een re-KOM-bin-ant)

Prevents infection caused by hepatitis A and hepatitis B viruses.

Brand Name(s):

Twinrix

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not receive this vaccine if you have had an allergic reaction to any type of hepatitis A or hepatitis B vaccine or to neomycin or yeast.

How to Use This Medicine:

Injectable

  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot into one of your muscles.
  • A nurse or other health provider will give you this medicine.
  • This vaccine is usually given as 3 doses. The second dose is given 1 month after the first dose. The third dose is then given 6 months later. However, your doctor may suggest a different schedule.

If a dose is missed:

  • It is important that you receive each dose at the right time. If you miss your scheduled shot, call your doctor to make another appointment as soon as possible.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using any medicine that weakens your immune system, such as a steroid (such as dexamethasone, prednisolone, prednisone, or Medrol®), radiation, or cancer medicine. Tell your doctor if you are using a blood thinner (such as warfarin, Coumadin®).

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, if you have ever had a serious reaction to any type of vaccine. Tell your doctor if you are sick, especially if you have a fever.
  • Make sure your doctor knows if you have a weak immune system. This could be caused by a disease or a medicine. The vaccine may not protect you completely if your immune system is weak, but you may still have some benefit.
  • Tell your doctor if you are allergic to latex. Some brands of this medicine are stored in packages that contain dry natural latex rubber.
  • This vaccine will not keep you from getting sick if you have already caught hepatitis A or B. This medicine will not protect you from hepatitis C.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash
  • Fainting, trouble seeing, numbness

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea, nausea
  • Headache
  • Redness, pain, swelling, or bruising where the shot was given
  • Tiredness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 11/4/2014


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