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Ribavirin (By mouth)

Ribavirin (rye-ba-VYE-rin)

Treats hepatitis C. Used together with an interferon medicine, such as Intron® A, Peg-Intron®, or Pegasys®.

Brand Name(s):

Copegus, Moderiba, Moderiba 1000 Dose Pack, Moderiba 1200 Dose Pack, Moderiba 600 Dose Pack, Moderiba 800 Dose Pack, Rebetol, RibaTab, Ribasphere, Ribasphere RibaPak, Ribasphere Ribapak, Ribavirin

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to ribavirin, or if you have serious liver problems that are getting worse (such as autoimmune hepatitis or cirrhosis). Do not use this medicine if you are pregnant or breastfeeding, if your female sexual partner is pregnant, or if you have a blood disorder (such as sickle-cell anemia or thalassemia major). Do not use this medicine together with didanosine (Videx®, Videx® EC).

How to Use This Medicine:

Capsule, Liquid, Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Ribavirin is used with other medicines to treat hepatitis C infection. Use all of the medicines your doctor has prescribed as part of your combination treatment. Ribavirin by itself will not treat hepatitis C.
  • Take this medicine one time in the morning and one time at night, unless your doctor tells you otherwise. It is best to take this medicine with food at the same time every day.
  • Swallow the capsule whole. Do not crush, break, or open it.
  • Drink extra fluids so you will urinate more often and help prevent kidney problems.
  • Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose. Ask your doctor what to do if you miss taking your medicine for more than 24 hours.

How to Store and Dispose of This Medicine:

  • Store the capsules and tablets at room temperature, away from heat, moisture, and direct light. Store the oral liquid in the refrigerator or at room temperature, away from heat and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using azathioprine (Azasan®, Imuran®) or medicine to treat HIV or AIDS (such as abacavir, lamivudine, stavudine, zidovudine, Trizivir®, or Ziagen®).
  • Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine:

  • This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant.
  • It is important to tell your doctor if you or your female sexual partner become pregnant. Your doctor may want you to join a pregnancy registry for patients taking this medicine.
  • To make sure you are not pregnant, your doctor may ask you to have a pregnancy test before you start using this medicine. You must have a negative pregnancy test before you will be allowed to take this medicine. You should test for pregnancy every month while you are using this medicine, and for 6 months after your treatment ends.
  • Use two forms of birth control to keep from getting pregnant while you are using this medicine (even if the medicine is temporarily stopped). Keep using two forms for at least 6 months after your treatment ends. This is very important for both men and women. Men using ribavirin might need to use a condom with a spermicide such as nonoxynol-9 as one form of birth control.
  • Make sure your doctor knows if you have kidney disease, liver disease (including hepatitis B), blood circulation problems, a blood disorder (such as anemia), breathing problems, lung disease, heart or blood vessel disease, high blood pressure, a history of heart attack, mental problems (such as depression or anxiety), or an addiction to drugs or alcohol.
  • Make sure your doctor knows if you have HIV or AIDS, cancer, colitis, diabetes, eye or vision problems, Gilbert's disease, pancreas problems, stomach problems, thyroid problems, any infection (such as flu), or an autoimmune disorder (such as psoriasis, lupus, or arthritis). Tell your doctor if you have lung disease such as sarcoidosis, or if you have had an organ transplant.
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Check with your doctor right away if you or your child have back, leg, or stomach pains; bleeding gums; chills; dark urine; difficulty breathing; fever; general body swelling; headache; loss of appetite; nausea or vomiting; nosebleeds; pale skin; sore throat; or yellowing of the eyes or skin. These could be symptoms of a blood disorder called anemia.
  • This medicine may cause serious types of allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you or your child have a rash; itching; hoarseness; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth while you are using this medicine.
  • Serious skin reactions can occur with this medicine. Check with your doctor right away if you or your child have blistering, peeling, or loosening of the skin; fever or chills; hives or welts; red skin lesions; a severe skin rash or acne; or sores or ulcers on the skin while you are using this medicine.
  • Pancreatitis may occur while you are using this medicine. Stop using this medicine and check with your doctor right away if you or your child have sudden and severe stomach pain, chills, constipation, nausea, vomiting, fever, or lightheadedness.
  • Check with your doctor if blurred vision, decreased vision, or any other change in vision occurs while you or your child are using this medicine. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).
  • This medicine will not keep you from giving hepatitis C to other people. Follow your doctor's instructions about how to prevent the spread of this infection.
  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
  • Ribavirin may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you, your child, or your caregiver notice any of these side effects, tell your doctor or your child's doctor right away.
  • Ribavirin used together with injectable peginterferon alfa-2a or peginterferon alfa-2b may affect your child's growth. Your doctor may need to check your child's height and weight during and after treatment with these medicines.
  • This medicine may cause teeth and gum problems. A dry mouth may also damage your teeth and gums if you take this medicine for a long time. To help prevent this condition, carefully brush your teeth at least two times a day and have regular visits with your dentist.
  • Some patients who have used this medicine may experience vomiting. If you vomit during your treatment, rinse your mouth out with water. This may also help prevent damage to your teeth and gums.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash.
  • Bloody or black, tarry stools.
  • Chest pain or uneven heartbeats.
  • Dark-colored urine or pale stools.
  • Depressed mood or thoughts of hurting yourself or others.
  • Diarrhea that may contain blood.
  • Feeling unusually cold or shivering.
  • Fever, chills, sore throat, sweating, and body aches.
  • High fever (temperature greater than 100 degrees F).
  • Problems with vision.
  • Shortness of breath or trouble with breathing.
  • Sudden and severe stomach pain, lower back pain, nausea, vomiting, or lightheadedness.
  • Unusual bleeding, bruising, pale skin, or weakness.
  • Worsening of psoriasis.
  • Yellowing of your skin or the whites of your eyes.

If you notice these less serious side effects, talk with your doctor:

  • Changes in taste.
  • Cough, runny or stuffy nose.
  • Dizziness.
  • Dry mouth or skin.
  • Hair loss.
  • Headache, irritability, or trouble with sleeping.
  • Memory problems.
  • Mild diarrhea, nausea, vomiting, stomach pain or upset, or loss of appetite.
  • Mild skin rash or itching.
  • Muscle or joint pain.
  • Tired feeling.
  • Weight loss.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 12/4/2014


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