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Enalapril/felodipine (By mouth)

Enalapril (en-AL-a-pril), Felodipine (fe-LOE-di-peen)

Treats high blood pressure. This medicine is a combination of an ACE (angiotensin-converting enzyme) inhibitor and a calcium channel blocker. The manufacturer stopped marketing this medicine on July 2, 2008.

Brand Name(s):

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to enalapril (Vaseretic®, Vasotec®) or to any other ACE inhibitors such as Accupril®, Altace®, Lotensin®, Lotrel®, Mavik®, Prinivil®, or Zestril®. You should not use this medicine if you are pregnant (especially in your second or third trimester), or if you have certain heart problems. Talk with your doctor about what these heart problems are.

How to Use This Medicine:

Long Acting Tablet

  • Take your medicine as directed.
  • It is best to take this medicine on an empty stomach.
  • Swallow the extended-release tablet whole. Do not crush, break, or chew it.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using cimetidine (Tagamet®), or a diuretic ("water pill") such as amiloride, furosemide, hydrochlorothiazide, triamterene, Lasix®, or Maxzide®. Tell your doctor if you are using lithium, or medicine to treat an infection (antibiotics) such as erythromycin. Your doctor will need to know if you are using a pain or arthritis medicine such as aspirin, diclofenac, ibuprofen, Advil®, Aleve®, Celebrex®, Ecotrin®, or Motrin®. Tell your doctor if you are using a medicine to treat fungal infections such as itraconazole, ketoconazole, or Nizoral®, or medicine for seizures such as carbamazepine, phenobarbital, phenytoin, Dilantin®, or Tegretol®.
  • Ask your doctor before you use any potassium supplements, or salt substitutes that contain potassium.
  • Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Make sure your doctor knows if you are breastfeeding, or if you have ever had an allergic reaction to a medicine. Tell your doctor if you have diabetes, kidney disease, liver disease, or a heart disease.
  • This medicine may cause swelling in some people. If you have swelling of your face, hands, arms, legs, feet, lips, tongue, or throat, call your doctor right away.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
  • Dizziness may be worse if you lose too much water from your body. You can lose water by sweating, having diarrhea, or vomiting. Tell your doctor if this medicine makes you dizzy or if you are vomiting or have diarrhea.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chest pain (may be related to your disease and not a side effect).
  • Confusion, weakness, shortness of breath, or numbness or tingling in your hands, feet, or lips.
  • Dark-colored urine or pale stools.
  • Lightheadedness or fainting.
  • Nausea, vomiting, loss of appetite, pain in your upper stomach.
  • Slow, fast, or uneven heartbeat.
  • Unexplained fever, chills, or sore throat.
  • Unusual bleeding, bruising, or weakness.
  • Yellowing of your skin or the whites of your eyes.

If you notice these less serious side effects, talk with your doctor:

  • Back or muscle pain.
  • Cough or dry throat.
  • Mild swelling of your gums.
  • Rapid weight gain.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 8/4/2014


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