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Voriconazole (By mouth)

Voriconazole (vor-i-KON-a-zole)

Treats fungal infections.

Brand Name(s):

Vfend

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to voriconazole or similar medicines, or if you are pregnant.

How to Use This Medicine:

Suspension, Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • It is best to take this medicine at least 1 hour before or 1 hour after a meal.
  • Shake the oral liquid well just before each use. Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.
  • Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Do not refrigerate or freeze the mixed suspension. Store it at room temperature and use it within 14 days.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use this medicine together with St John's wort, astemizole, barbiturates (such as phenobarbital), carbamazepine, cisapride, efavirenz, ergot medicines (dihydroergotamine, ergotamine), pimozide, quinidine, rifabutin, rifampin, ritonavir, sirolimus, or terfenadine.
  • Some medicines can affect how voriconazole works. Tell your doctor if you are using alfentanil, cyclosporine, everolimus, fentanyl, fluconazole, methadone, omeprazole, oxycodone, phenytoin, tacrolimus, vinblastine, vincristine, blood pressure medicines, diabetes medicines that you take by mouth (glipizide, glyburide, tolbutamide), medicines to lower cholesterol, medicines to treat HIV or AIDS (amprenavir, delavirdine, nelfinavir, nevirapine, saquinavir), medicines for anxiety or sleeping (alprazolam, midazolam, triazolam), NSAID pain medicines (such as aspirin, celecoxib, diclofenac, ibuprofen, naproxen), a blood thinner (such as warfarin), or birth control pills.

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, heart disease, heart rhythm problems, or low levels of potassium, magnesium, or calcium. Tell your doctor if you recently had cancer treatment or a stem cell transplant. Tell your doctor if you have a condition that makes it hard for you to digest sugars or dairy products.
  • This medicine may cause the following problems:
    • Liver problems
    • Changes in heart rhythm, such as QT prolongation
    • Serious skin reactions
    • Bone pain (if used for a long period of time)
  • This medicine may cause changes in vision. Do not drive (especially at night) or do anything that could be dangerous until you know how this medicine affects you.
  • This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.
  • Call your doctor if your symptoms do not improve or if they get worse.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash
  • Bone pain
  • Change in how much or how often you urinate, or painful urination
  • Changes in vision, light sensitivity, or problems seeing colors
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Fast, pounding, or uneven heartbeat
  • Sudden or severe stomach pain, nausea, vomiting, fever, lightheadedness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 9/4/2014


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