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Lansoprazole/amoxicillin/clarithromycin (By mouth)

Treats a stomach infection (H pylori) that causes ulcers. This medicine is a combination of an antacid and two different antibiotics.

Brand Name(s):

Prevpac, Triple Therapy

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to lansoprazole, amoxicillin, clarithromycin, or to any penicillin or macrolide antibiotic such as azithromycin, erythromycin, Zithromax®, or Biaxin®. You should not use this medicine if you are also using cisapride (Propulsid®), pimozide (Orap®), or terfenadine (Seldane®).

How to Use This Medicine:

Capsule, Tablet, Delayed Release Capsule

  • Take your medicine as directed.
  • Swallow the capsule or tablet whole. Do not chew, crush, or break any of them.
  • It is best to take this medicine on an empty stomach, before a meal.
  • Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • There are many other drugs that can interact with this combination of medicines. Make sure your doctor knows about all other medicines you are using.
  • Tell your doctor if you are also using astemizole (Hismanal®), carbamazepine (Tegretol®), chloramphenicol, digoxin (Lanoxin®), iron, ketoconazole (Nizoral®), tetracycline, theophylline, or Viagra®.
  • It is important for your doctor to know if you use any of the following: a blood thinner such warfarin (Coumadin®), a sulfa drug, a heart rhythm medicine, a sedative such as Xanax® or Halcion®, ergot medicine such as Cafergot® or Wigraine®, or medicine to lower cholesterol, such as Lipitor® or Zocor®. Tell your doctor if you use medicines to treat HIV/AIDS, such as Agenerase®, Crixivan®, Invirase®, Norvir®, Retrovir®, Sustiva®, or Viracept®.
  • Make sure your doctor knows about all other antibiotics you are using, especially ampicillin, azithromycin (Zithromax®) or erythromycin (E.E.S., Ery-Tab®, E-Mycin®).
  • If you are also taking sucralfate (Carafate®), you should take the medicines in Prevpac® at least 30 minutes before taking sucralfate.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breast feeding. Tell your doctor if you have kidney disease or diabetes. Tell your doctor if you are allergic to cephalosporin antibiotics (such as cefaclor, cefadroxil, cephalexin, Ceftin®, Keflex®) or any other medicines.
  • Ask your doctor before you take any medicine to stop severe diarrhea.
  • Call your doctor if your symptoms do not improve or if they get worse.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash.
  • Dark-colored urine or pale stools.
  • Diarrhea that may contain blood.
  • Fast or irregular heartbeat.
  • Fever, chills, cough, sore throat, body aches.
  • Nausea, vomiting, loss of appetite, pain in your upper stomach.
  • Yellowing of your skin or the whites of your eyes.

If you notice these less serious side effects, talk with your doctor:

  • Bad taste in your mouth.
  • Change in the color of your teeth or tongue.
  • Headache or stomach pain.
  • Nausea.
  • Vaginal itching or discharge.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 4/4/2014
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