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Rasburicase (Injection)

Rasburicase (ras-BURE-i-kase)

Treats high levels of uric acid, which can be a side effect of some cancer treatments. This medicine is used in adults and children with certain types of cancer (such as leukemia, lymphoma, and tumors).

Brand Name(s):

Elitek

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You or your child should not receive this medicine if you have had an allergic reaction to rasburicase, or if you have glucose-6-phosphatase dehydrogenase (G6PD) deficency. You or your child should not receive this medicine if you have a history of serious blood problems (such as hemolysis or methemoglobinemia).

How to Use This Medicine:

Injectable

  • You will receive this medicine in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
  • The medicine must be injected slowly, so the needle will need to stay in place for up to 30 minutes.

If a dose is missed:

  • You must use this medicine on a fixed schedule. Call your doctor or pharmacist if you miss a dose.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding.
  • This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you or your child have a rash; itching; dizziness; lightheadedness; swelling of your hands, face, or mouth; trouble with breathing; or chest pain after you get the injection.
  • Tell your doctor if you are of African or Mediterranean descent, because people with this ancestry are more likely to have G6PD deficiency.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Bluish-colored lips, fingernails, or skin.
  • Chills, fever, back and stomach pain, or dark-colored urine.
  • Lightheadedness or fainting.
  • Skin rash.
  • Swelling in your hands, ankles, or feet.
  • Unusual bleeding, bruising, or weakness.
  • Yellowing of your skin or the whites of your eyes.

If you notice these less serious side effects, talk with your doctor:

  • Anxiety.
  • Headache.
  • Mouth sores or white patches in your mouth or throat.
  • Nausea, vomiting, diarrhea, constipation, or stomach pain.
  • Pain, redness, or swelling at the injection site.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 4/4/2014
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