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Irbesartan/hydrochlorothiazide (By mouth)

Hydrochlorothiazide (hye-droe-klor-oh-THYE-a-zide), Irbesartan (ir-be-SAR-tan)

Treats high blood pressure. A lower blood pressure can reduce the risk of stroke and heart attack. This medicine contains an angiotensin receptor blocker (ARB) and a thiazide diuretic (water pill).

Brand Name(s):

Avalide

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to irbesartan, hydrochlorothiazide, or a sulfonamide (sulfa drug), or if you are pregnant. Do not use this medicine if you are not able to urinate. Do not use this medicine together with aliskiren (Tekturna®) if you have diabetes.

How to Use This Medicine:

Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Drink plenty of fluids if you exercise, sweat more than usual, or have diarrhea or vomiting while you are using this medicine.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using carbamazepine (Tegretol®), lithium (Eskalith®, Lithobid®), a diuretic (water pill, such as amiloride, furosemide, spironolactone, triamterene, Lasix®), another blood pressure medicine (such as aliskiren, benazepril, enalapril, lisinopril, Avalide®, Avapro®, Benicar®, Cozaar®, Diovan®, Lotrel®, Micardis®, Tekturna®, Vasotec®, Zestril®, Zestoretic®), or an NSAID pain or arthritis medicine (such as aspirin, diclofenac, ibuprofen, naproxen, Advil®, Aleve®, Celebrex®, Voltaren®).
  • Tell your doctor if you are using a medicine to lower cholesterol (such as cholestyramine, colestipol, Colestid®, Questran®), a steroid medicine (such as dexamethasone, hydrocortisone, methylprednisolone, prednisolone, prednisone, Medrol®), or insulin or diabetes medicine that you take by mouth (such as glimepiride, glyburide, metformin, Actos®, Janumet®, Januvia®).
  • Ask your doctor before you use any medicine, supplement, or salt substitute that contains potassium.
  • Drinking alcohol or taking narcotic pain relievers or sleeping pills with this medicine may intensify feeling lightheaded, dizzy, or faint. Tell your doctor if you drink alcohol or use pain relievers or sleeping pills.

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Make sure your doctor knows if you are breastfeeding, or if you have kidney problems, liver disease, congestive heart failure, diabetes, glaucoma, gout, high cholesterol, or lupus. Tell your doctor if you have a mineral imbalance (such as high or low calcium, magnesium, potassium, or sodium in the blood) or a history of asthma or allergies.
  • This medicine could lower your blood pressure too much and cause you to feel dizzy or lightheaded. Stand or sit up slowly if you are dizzy. This is more likely to happen when you begin to use the medicine or if you become dehydrated.
  • Call your doctor immediately if you have blurred vision, trouble seeing, eye pain, or any other change in vision. These could be symptoms of glaucoma, which could cause permanent damage to your vision.
  • Do not stop using this medicine without asking your doctor, even if you feel well. This medicine will not cure your high blood pressure, but it will help keep it in normal range. You may have to take blood pressure medicine for the rest of your life.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Blurred vision, eye pain
  • Chest pain
  • Confusion, weakness, muscle twitching
  • Decrease in how much or how often you urinate
  • Dry mouth, increased thirst, muscle cramps
  • Fast, slow, pounding, or uneven heartbeat
  • Lightheadedness, dizziness, fainting
  • Nausea, vomiting, loss of appetite, pain in your upper stomach, yellow skin or eyes
  • Numbness or tingling in your hands, feet, or lips
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Muscle pain
  • Tiredness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 10/4/2014


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