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Eplerenone (By mouth)

Eplerenone (e-PLER-en-one)

Treats high blood pressure. A lower blood pressure can reduce the risk of stroke and heart attack. Also treats congestive heart failure (CHF) after a heart attack.

Brand Name(s):

Inspra

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to eplerenone, if you have high blood potassium, or if you are also using clarithromycin (Biaxin®), itraconazole (Sporanox®), ketoconazole (Nizoral®), nefazodone (Serzone®), nelfinavir (Viracept®), ritonavir (Norvir®), or troleandomycin. Some people with kidney disease should not use this medicine, but it will depend on how severe the kidney disease is. Do not use this medicine to lower your blood pressure if you have type 2 diabetes with microalbuminuria, or if you use potassium supplements, salt substitutes, or certain diuretics (water pills, such as spironolactone, triamterene, or amiloride).

How to Use This Medicine:

Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Carefully follow your doctor's instructions about any special diet. Be sure to drink plenty of fluids if you exercise, sweat more than usual, or have diarrhea or vomiting.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you also use erythromycin (Erythro-Tab®), fluconazole (Diflucan®), lithium (Eskalith®, Lithobid®), saquinavir (Fortovase®), other blood pressure medicine (such as benazepril, enalapril, lisinopril, verapamil, Avalide®, Avapro®, Benicar®, Calan®, Cozaar®, Diovan®, Lotrel®, Micardis®, Vasotec®, Zestoretic®, Zestril®), or pain or arthritis medicine (NSAID, such as aspirin, diclofenac, ibuprofen, naproxen, Advil®, Aleve®, Celebrex®, Voltaren®).

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, or diabetes.
  • Call your doctor right away if you have dizziness, confusion, difficulty breathing, nausea or vomiting, diarrhea, uneven heartbeats, weakness or heaviness of the legs, or numbness or tingling in the hands, feet, or lips.
  • Even if you feel well, do not stop using the medicine without asking your doctor. This medicine will not cure your high blood pressure, but it will help keep it in the normal range. You may have to take blood pressure medicine for the rest of your life.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chest pain
  • Cloudy urine
  • Confusion, weakness, uneven heartbeat, trouble breathing, numbness or tingling in your hands, feet, or lips
  • Dry mouth, increased thirst, muscle cramps, nausea, vomiting
  • Unusual tiredness or weakness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 9/4/2014


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