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Belladonna alkaloids/phenobarbital (By mouth)

Atropine (AT-roe-peen), Hyoscyamine (hye-oh-SYE-a-meen), Phenobarbital (fee-noe-BAR-bi-tal), Scopolamine (skoe-POL-a-meen)

Treats irritable bowel syndrome (relieves spasms and cramping) and ulcers.

Brand Name(s):

Antispasmodic, Donnatal, Donnatal Extentabs

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had any allergic reaction to atropine, hyoscyamine, scopolamine, or phenobarbital.

How to Use This Medicine:

Liquid, Tablet, Long Acting Tablet, Capsule

  • Take your medicine as directed.
  • Take this medicine 30 to 60 minutes before meals unless your doctor tells you differently.
  • Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.
  • Swallow thetablet whole. Do not chew, crush, or break.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store at room temperature, away from heat, moisture, and direct light.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Avoid drinking alcohol.
  • Wait 2 to 3 hours after your dose of this medicine before taking antacids (such as Maalox® or Mylanta®) or medicine to stop diarrhea.
  • Make sure your doctor knows if you are taking blood thinners (Coumadin®), ketoconazole (Nizoral®), MAO inhibitors (such as Nardil® or Parnate®) or any medicines that could make you sleepy such as sleeping pills, cold or allergy medicine, antidepressants, tranquilizers, or strong pain killers.

Warnings While Using This Medicine:

  • Check with your doctor before taking this medicine if you have liver or kidney disease, glaucoma, enlarged prostate or trouble urinating, intestinal problems, or any other medical problems.
  • If you are pregnant or breastfeeding, talk to your doctor before taking this medicine.
  • This medicine may make you sweat less and cause your body to get too hot. Be careful in hot weather, especially if you are exercising, working, or using a sauna or whirlpool.
  • You should not use this medicine more often or in larger doses than ordered by your doctor.
  • This medicine may cause dizziness or blurred vision. Be careful if you are driving a car or using machinery.
  • Your eyes may become more sensitive to bright light because of this medicine. If this is a problem, you may want to wear sunglasses.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Unusual bleeding or bruising
  • Sore throat or fever
  • Skin rash or hives
  • Fast or irregular heartbeat
  • Trouble urinating or unable to urinate
  • Slurred speech or confusion
  • Eye pain

If you notice these less serious side effects, talk with your doctor:

  • Constipation
  • Dizziness or drowsiness
  • Dry throat, mouth, nose, or skin
  • Blurred vision

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 11/4/2014


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