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Pentazocine/naloxone (By mouth)

Naloxone (nal-OX-one), Pentazocine (pen-TAZ-oh-seen)

Relieves moderate to severe pain. This medicine is a narcotic analgesic ("pain medicine").

Brand Name(s):

Talwin NX

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to pentazocine or naloxone.

How to Use This Medicine:

Tablet

  • Take your medicine as directed.
  • You may take this medicine with food or milk to avoid stomach upset.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Make sure you store the medicine in a safe and secure place to prevent others from getting it.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you have received a MAO inhibitor (MAOI) such as Eldepryl®, Marplan®, Nardil®, or Parnate® within the past 14 days. Tell your doctor if you are also using an anticholinergic medicine (such as ipratropium, glycopyrrolate, or Atrovent®) or a phenothiazine medicine (such as prochlorperazine, Compazine®, Mellaril®, Phenergan®, Thorazine®, or Trilafon®).
  • Avoid tobacco smoking while you are using this medicine.
  • Tell your doctor if you drink alcohol or if you are using any medicine that makes you sleepy, such as allergy medicine or narcotic pain medicine.
  • Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart or blood vessel disease, low blood pressure, a recent heart attack, or a history of head injury, seizures, or recent surgery. Tell your doctor if you have adrenal problems, asthma or other lung problems (such as COPD, respiratory depression), gallbladder problems, kyphoscoliosis (severe curvature of the spine with breathing problems), mental illness, pancreas problems, porphyria (an enzyme problem), prostate problems, bowel blockage, stomach problems, trouble urinating, or an underactive thyroid. Tell your doctor if you have been addicted to alcohol or drugs.
  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
  • This medicine may make you dizzy, drowsy, or lightheaded. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert. Change positions slowly when getting up from a sitting or lying position.
  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash.
  • Decrease in how much or how often you urinate.
  • Extreme weakness, shallow breathing, sweating, or cold or clammy skin.
  • Fast, slow, or uneven heartbeat.
  • Fever, chills, cough, sore throat, and body aches.
  • Lightheadedness, dizziness, or fainting.
  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet.
  • Seizures or tremors.
  • Severe confusion or hallucinations (seeing things that are not there).
  • Severe stomach pain.
  • Sleepiness or unusual drowsiness.

If you notice these less serious side effects, talk with your doctor:

  • Blurred vision.
  • Constipation, diarrhea, nausea, vomiting, loss of appetite, stomach pain, or upset stomach.
  • Dry mouth.
  • Headache.
  • Mild rash or itching skin.
  • Trouble sleeping.
  • Warmth or redness in your face, neck, arms, or upper chest.
  • Weakness.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 7/4/2014


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