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Diphenhydramine/zinc (On the skin)

Diphenhydramine (dye-fen-HYE-dra-meen), Zinc (zink), Zinc Acetate (zink AS-e-tate), Zinc Oxide (zink OX-ide)

Treats pain and itching caused by insect bites, minor cuts or burns, or sunburn. Also treats skin rash caused by poison ivy, poison oak, or poison sumac.

Brand Name(s):

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to diphenhydramine or zinc. Do not use this medicine for chickenpox or measles. Do not use on large areas of skin, or on rash areas that have blisters or broken skin. You should not use this medicine if you are also taking diphenhydramine (Benadryl®) by mouth.

How to Use This Medicine:

Stick, Lotion, Gel/Jelly, Spray, Cream, Ointment

  • Take your medicine as directed.
  • Follow the instructions on the medicine label if you are using this medicine without a prescription.
  • Do not apply the medicine more than 4 times each day.
  • Use this medicine only on your skin. Rinse it off right away if it gets on a cut or scrape. Do not get the medicine in your eyes, nose, or mouth.
  • Wash your hands with soap and water before and after you use this medicine.
  • Apply a thin layer of the medicine to the affected area. Rub it in gently. Press tip of stick on affected skin area until liquid medicine flows, then dab lightly.
  • Do not cover the treated area with a bandage unless directed by your doctor.

If a dose is missed:

  • Apply a dose as soon as you can. If it is almost time for your next dose, wait until then and apply a regular dose. Do not apply extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • The stick form of this medicine is flammable. Keep the medicine away from fire or open flame.
  • Ask your pharmacist or doctor how to dispose of the medicine container and any leftover or expired medicine.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not put cosmetics or skin care products on the treated skin.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breast feeding.
  • Call your doctor if your symptoms do not improve or if they get worse.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Worsened skin rash, itching, redness, or swelling.

If you notice these less serious side effects, talk with your doctor:

  • Return of your skin symptoms a few days after they have cleared up.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 8/4/2014


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