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Dexrazoxane (Injection)

Dexrazoxane (dex-ray-ZOX-ane)

Prevents heart problems in women receiving a breast cancer medicine called doxorubicin (Adriamycin®, Doxil®). Also prevents or treats tissue damage caused by the leakage of certain anticancer medicines from the blood vessels.

Brand Name(s):

Totect, Zinecard

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not receive this medicine if you have had an allergic reaction to dexrazoxane.

How to Use This Medicine:

Injectable

  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
  • You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
  • This medicine is usually given 30 minutes before doxorubicin is given.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using dimethylsulfoxide (DMSO) before you start receiving this medicine.

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Make sure your doctor knows if you are breastfeeding, or if you have liver disease, kidney disease, or blood disorder.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Avoid people who are ill, and wash your hands often. Brush and floss your teeth gently, do not play rough sports, and be careful with sharp objects.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chest pain or shortness of breath.
  • Dark-colored urine or pale stools.
  • Fever, chills, cough, sore throat, and body aches.
  • Nausea, vomiting, loss of appetite, pain in your upper stomach.
  • Swelling in your hands, ankles, or feet.
  • Unusual bleeding or bruising.
  • Unusual tiredness or weakness.
  • Yellowing of your skin or the whites of your eyes.

If you notice these less serious side effects, talk with your doctor:

  • Depression.
  • Diarrhea or constipation.
  • Dizziness or headache.
  • Hair loss.
  • Muscle pain.
  • Pain, burning, redness, or swelling under your skin where the needle is placed.
  • Sores or white patches on your lips, mouth, or throat.
  • Trouble sleeping.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 4/4/2014
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