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Orphenadrine (Injection)

Orphenadrine Citrate (or-FEN-a-dreen SIT-rate)

Used with rest, physical therapy, and other measures to relieve discomfort caused by certain health problems or by injuries (such as sprains or strains).

Brand Name(s):

Antiflex, Mio-Rel, Norflex, Orfro

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to orphenadrine. You should not use this medicine if you have glaucoma, myasthenia gravis, an enlarged prostate, or urinary tract blockage. Ask your doctor before using this medicine if you have digestive tract problems such as a stomach ulcer, intestinal blockage, or megaesophagus (enlarged or dilated esophagus).

How to Use This Medicine:

Injectable

  • Your doctor will prescribe your exact dose and how often it should be given. This medicine is given as a shot into a muscle or a vein.
  • A nurse or other health provider will give you this medicine.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using propoxyphene (such as Darvon® or Darvocet®).

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding.
  • Make sure your doctor knows if you have asthma, heart problems, or an allergy to sulfites.
  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Confusion, anxiety, unusual thoughts, or hallucinations (sensing things that are not there).
  • Fast or pounding heartbeat.
  • Lightheadedness or fainting.

If you notice these less serious side effects, talk with your doctor:

  • Blurred vision.
  • Dry mouth.
  • Headaches.
  • Stomach upset, nausea and vomiting, or constipation.
  • Weakness, tremors, or shaking.
  • Trouble urinating, or a decrease in how much or how often you urinate.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 8/4/2014


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