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Duloxetine (By mouth)

Duloxetine (doo-LOX-e-teen)

Treats depression, anxiety, diabetic peripheral neuropathy, fibromyalgia, or chronic muscle or bone pain. This medicine is an SSNRI.

Brand Name(s):

Cymbalta

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to duloxetine, or if you have uncontrolled narrow-angle glaucoma.

How to Use This Medicine:

Delayed Release Capsule, Capsule

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Delayed-release capsule: Swallow the capsule whole. Do not crush, chew, or break the capsule. Do not open the capsule and sprinkle the contents on food or in liquids.
  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not take duloxetine if you have used an MAO inhibitor (MAOI) within the past 14 days. Do not start taking an MAO inhibitor within 5 days of stopping duloxetine.
  • Some medicines can affect how duloxetine works. Tell your doctor if you are also using St John's wort, cimetidine, lithium, thioridazine, tramadol, or tryptophan. Also tell your doctor if you are using other medicine to treat depression, blood pressure medicine, medicine for heart rhythm problems, medicine to treat headaches, medicine to treat an infection, an NSAID pain or arthritis medicine (such as aspirin, celecoxib, diclofenac, ibuprofen, naproxen), a phenothiazine medicine, a diuretic (water pill), or a blood thinner (such as warfarin).
  • Tell your doctor if you drink alcohol or if you are using any medicine that makes you sleepy, such as allergy medicine or narcotic pain medicine.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, diabetes, narrow-angle glaucoma, problems with urination, digestion problems, heart disease, high or low blood pressure, or low sodium in the blood. Also tell your doctor if you have a history of seizures, mania, or drug or alcohol addiction. Tell your doctor if you drink alcohol.
  • For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts.
  • This medicine may cause the following problems:
    • Serotonin syndrome
    • Liver problems
    • Low sodium in the blood
    • Increased risk of bleeding
  • This medicine may make you dizzy or drowsy. Do not drive or doing anything else that could be dangerous until you know how this medicine affects you. Stand or sit up slowly if needed.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Anxiety, restlessness, fever, fast heartbeat, sweating, muscle spasms, nausea, vomiting, diarrhea, seeing or hearing things that are not there
  • Blistering, peeling, or red skin rash
  • Confusion, weakness, muscle twitching
  • Dark urine or pale stools, loss of appetite, stomach pain, yellow skin or eyes
  • Decrease in how much or how often you urinate
  • Feeling more energetic than usual
  • Lightheadedness, dizziness, or fainting
  • Unusual behavior, or thoughts about hurting yourself or others
  • Unusual bleeding or bruising

If you notice these less serious side effects, talk with your doctor:

  • Decreased appetite
  • Dry mouth, constipation, nausea
  • Sexual problems
  • Tiredness, unusual drowsiness, or trouble sleeping

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 8/4/2014


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