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Methylene blue (Intravenous)

Methylene Blue (METH-i-leen BLOO)

Treats methemoglobinemia (a condition where your blood cannot carry oxygen properly, usually because you have been exposed to a certain drug or chemical).

Brand Name(s):

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not receive this medicine if you have had an allergic reaction to methylene blue, or if you are pregnant.

How to Use This Medicine:

Injectable

  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
  • A nurse or other health provider will give you this medicine.
  • This medicine must be given very slowly, so the needle will remain in place for several minutes.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using medicines to treat depression (such as amitriptyline, bupropion, citalopram, desipramine, duloxetine, escitalopram, fluoxetine, fluvoxamine, imipramine, nortriptyline, paroxetine, sertraline, venlafaxine, Aventyl®, Celexa®, Cymbalta®, Effexor®, Elavil®, Lexapro?, Luvox®, Norpramin®, Pamelor®, Paxil®, Prozac®, Tofranil®, Wellbutrin®, or Zoloft®), medicine to treat migraine headaches (such as eletriptan, sumatriptan, zolmitriptan, Imitrex®, Relpax®, or Zomig®), ergot medicine (such as ergotamine, Cafergot®, Ergomar®, or Wigraine®), or certain antibiotics (linezolid, Zyvox®).

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Make sure your doctor knows if you are breastfeeding, or if you have kidney disease or a condition called glucose-6-phosphate dehydrogenase (G6PD) deficiency.
  • Make sure your doctor knows about all the other medicines you are using. This medicine may cause a serious condition called serotonin syndrome when taken with certain medicines. Check with your doctor first before taking any other medicines. The symptoms of serotonin syndrome include mental changes (confusion, hyperactivity, memory problems), muscle twitching, excessive sweating, shivering or shaking, diarrhea, trouble with coordination, or fever.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments. Blood tests may be needed to check for unwanted effects.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chest pain.
  • Severe shortness of breath.

If you notice these less serious side effects, talk with your doctor:

  • Confusion or dizziness.
  • Headache.
  • Heavy sweating.
  • Nausea or stomach pain.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 10/4/2014


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