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Cyclosporine (Injection)

Cyclosporine (sye-kloe-SPOR-een)

Helps prevent organ rejection after transplant surgery.

Brand Name(s):

SandIMMUNE

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. You should not receive it if you had an allergic reaction to cyclosporine or castor oil.

How to Use This Medicine:

Injectable

  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
  • A nurse or other health provider will give you this medicine.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • The list below includes some of the most commonly used medicines that can interact with cyclosporine. There are many other drugs not listed. Make sure your doctor knows the names of all the medicines you use. Tell your doctor if you are taking any of the following:
    • St John's wort, amiodarone, boceprevir, bromocriptine, colchicine, danazol, digoxin, methotrexate, metoclopramide, orlistat, sulfinpyrazone, tacrolimus, ticlopidine, or telaprevir
    • Any medicine to treat an infection, an NSAID pain or arthritis medicine (such as aspirin, diclofenac, ibuprofen, naproxen, celecoxib), birth control pills, medicine for seizures, medicine to lower cholesterol, a steroid, a diuretic (water pill), high blood pressure medicine, a potassium supplement, or medicine or treatment for psoriasis, including PUVA or UVB light therapy
  • If you are using sirolimus, take it 4 hours after you receive cyclosporine.
  • This medicine may interfere with vaccines. Ask your doctor before you get a flu shot or any other vaccines.
  • Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, anemia, a bleeding disorder, high blood pressure, eye or vision problems, or a history of seizures.
  • This medicine may cause the following problems:
    • Increased risk of infections
    • Increased risk of cancer, including skin cancer
    • Liver problems
    • Kidney problems
    • Hyperkalemia (high potassium levels in the blood)
    • High blood pressure
    • Nervous system disorder
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Change in how much or how often you urinate, bloody urine
  • Confusion, weakness, uneven heartbeat, trouble breathing, or numbness in your hands, feet, or lips
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Fast heartbeat, dizziness, headache, vision changes
  • Fever, chills, cough, sore throat, or body aches
  • Rapid weight gain, swelling in your face, hands, feet, or lower legs
  • Seizures or tremors
  • Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea, stomach pain
  • Increased hair growth, especially on your face
  • Swelling of your gums

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 11/4/2014


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