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Corticotropin (Injection)

Corticotropin, Repository (kor-ti-koe-TROE-pin ree-POZ-i-tor-ee)

Treats infantile spasms (seizures). Also treats multiple sclerosis, endocrine (gland and hormone) disorders, arthritis, lupus, and many other medical conditions.

Brand Name(s):

H.P. Acthar

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to corticotropin or pork proteins. You should not use this medicine if you have adrenal problems, congenital (inborn) infections, congestive heart failure, uncontrolled high blood pressure, peptic ulcer, or a recent surgery. Do not use this medicine if you have bone problems (osteoporosis), fungus infections, herpes infection in the eyes, or an autoimmune disease called scleroderma. You or your child should not receive live vaccines while using this medicine.

How to Use This Medicine:

Injectable

  • Your doctor will prescribe the exact dose and tell you how often it should be given. This medicine is given as a shot under your skin or into one of your muscles.
  • A nurse or other health provider will give you this medicine.
  • You may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.
  • Carefully follow your doctor's instructions about any special diet.
  • If you are using the gel form of this medicine, allow it to warm to room temperature before using it.
  • You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas.
  • Use a new needle and syringe each time you inject your medicine.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

If a dose is missed:

  • You must use this medicine on a fixed schedule. Call your doctor or pharmacist if you miss a dose.

How to Store and Dispose of This Medicine:

  • If you store this medicine at home, keep it in the refrigerator. Do not freeze.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine, containers, and other supplies. Throw away old medicine after the expiration date has passed.
  • Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using aspirin or diuretics ("water pills") such as furosemide, hydrochlorothiazide, Aldactazide®, Aldactone®, Dyazide®, Hyzaar®, Lasix®, Maxzide®, or Moduretic®.
  • This medicine may interfere with vaccines. Ask your doctor before you get a flu shot or any other vaccines.

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease (including cirrhosis), edema (fluid retention), controlled high blood pressure, low potassium in the blood, underactive thyroid, or an adrenal problem called Cushing's syndrome. Tell your doctor if you have any type of infection, depression, diabetes, emotional problems, eye problems (such as cataracts, glaucoma), mental illness, myasthenia gravis (severe muscle weakness), stomach ulcers or bleeding, tuberculosis, or a bowel disorder called diverticulitis.
  • You may get infections more easily while using this medicine. Avoid being near people who are sick or have infections while you are using this medicine. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.
  • Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems (e.g., Cushing's syndrome). The risk is greater for children and patients who use large amounts for a long time. Talk to your doctor right away if you or your child have more than one of these symptoms while you are using this medicine: blurred vision; dizziness or fainting; a fast, irregular, or pounding heartbeat; fractures; increased thirst or urination; irritability; round or "moon" face, neck, or trunk; stomach pain; thin skin or easy bruising; weight gain or loss; or unusual tiredness or weakness.
  • This medicine may mask or hide symptoms of other diseases while you are using it. Check with your doctor if you or your child have symptoms of infection; black, tarry stools; changes in body weight; difficulty with breathing; fast heart rate; increased thirst; stomach pain; unusual tiredness; or vomiting.
  • Check with your doctor right away if you start having severe abdominal or stomach burning, cramps, or pains; bloody or black, tarry stools; constipation or diarrhea; heartburn; indigestion; nausea; or vomiting of material that looks like coffee grounds. These could be symptoms of a serious stomach or bowel problem.
  • This medicine may cause changes in mood and behavior. Check with your doctor if you or your child have trouble sleeping, feeling depressed or irritable, mood swings, or other changes in behavior.
  • Check with your doctor right away if you or your child have any changes to your eyes, such as redness, itching, swelling, or vision changes while you are using this medicine. Your doctor may want you to have your eyes checked by an eye doctor.
  • This medicine may decrease bone mineral density when used for a long time. A low bone mineral density can cause slow growth and may lead to osteoporosis at any age. If you have any questions about this ask your doctor.
  • This medicine may raise or lower your blood sugar level.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments. Blood tests may be needed to check for unwanted effects.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Black, tarry stools.
  • Blurred vision or severe pain in your eye.
  • Dry mouth, increased thirst, muscle cramps, nausea, or vomiting.
  • Fast, pounding, or uneven heartbeat.
  • Fever, chills, cough, sore throat, and body aches.
  • Gaining weight around your neck upper back, breast, upper back, breast, face, or waist.
  • Increase in how much and how often you urinate, or increased thirst and appetite.
  • Round or "moon" face.
  • Severe headache, seizures, or lightheadedness.
  • Severe pain in your back or spine.
  • Shortness of breath, cold sweat, or bluish-colored skin.
  • Stomach ulcer or ulcers in your food pipe.
  • Sudden and severe stomach pain.
  • Swelling in your hands, ankles, or feet.
  • Vomiting of material that looks like coffee grounds.

If you notice these less serious side effects, talk with your doctor:

  • Acne, redness in your face, or bruising or darkening of your skin.
  • Constipation or diarrhea.
  • Dizziness.
  • Excessive sweating.
  • Feeling depressed, irritable, or other changes in behavior.
  • Hair growth around lips or chin in women.
  • Irregular menstrual periods.
  • Muscle pain, tenderness, or weakness.
  • Weight gain.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 11/4/2014


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